The first total synthesis of nakadomarin A
The first total synthesis of nakadomarin A
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DOI：
10.1021/ja034464j
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发表时间：
2003-06-25
影响因子：
15
通讯作者：
Nishida, A
中科院分区：
文献类型：
--
作者：
Nagata, T;Nakagawa, M;Nishida, A
(−)-Nakadomarin A 是从海绵中分离出来的曼扎明生物碱的成员，具有独特的六环结构。 (+)-nakadomarin A（一种天然产物的对映体）的首次全合成是由立体化学定义的 4-氧代哌啶-3-羧酸衍生物完成的。该合成建立了 nakadomarin A 的结构，包括绝对构型。
(−)-Nakadomarin A is a member of manzamine alkaloid isolated from a marine sponge and have a unique hexacyclic structure. The first total synthesis of (+)-nakadomarin A, an enantiomer of natural product, has been accomplished from stereochemically defined 4-oxopiperidin-3-carboxylic acid derivative. The synthesis established the structure of nakadomarin A including absolute configuration.