Blood flow dynamics in patient-specific cerebral aneurysm models: The relationship between wall shear stress and aneurysm area index
Blood flow dynamics in patient-specific cerebral aneurysm models: The relationship between wall shear stress and aneurysm area index
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DOI：
10.1016/j.medengphy.2007.04.011
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发表时间：
2008-04-01
影响因子：
2.2
通讯作者：
Galvez, Marcelo
中科院分区：
文献类型：
--
作者：
Valencia, Alvaro;Morales, Hernan;Galvez, Marcelo
血流动力学在脑动脉瘤的进展和破裂中起重要作用。动脉瘤囊壁面切应力（WSS）的时空变化与动脉瘤的生长和破裂有关。目前的工作描述了位于Willis环前循环和后循环区域的34例囊状动脉瘤患者特定模型的血流动力学。该模型是从三维旋转血管造影图像数据和血流动力学进行了研究的生理代表性波形的流入。采用非结构化细网格，用商业软件求解三维非定常层流连续性方程和动量方程。涡流结构、壁压和WSS显示出较大的变化，取决于动脉的形态、动脉瘤的大小和形式。外侧未破裂和破裂动脉瘤的动脉瘤囊上的平均WSS与动脉瘤表面指数之间存在相关性，动脉瘤表面指数分别定义为模型入口处动脉瘤面积与动脉面积之间的比值。(C)2007年妇女平等问题国际研究所。由爱思唯尔有限公司出版。保留所有权利。
Hemodynamics plays an important role in the progression and rupture of cerebral aneurysms. The temporal and spatial variations in wall shear stress (WSS) within the aneurysmal sac are hypothesized to be correlated with the growth and rupture of the aneurysm. The current work describes the blood flow dynamics in 34 patient-specific models of saccular aneurysms located in the region of the anterior and posterior circulation of the circle of Willis. The models were obtained from three-dimensional rotational angiography image data and blood flow dynamics was studied under a physiologically representative waveform of inflow. The three-dimensional continuity and momentum equations for unsteady laminar flow were solved with commercial software using non-structured fine grid sizes. The vortex structure, the wall pressure, and the WSS showed large variations, depending on the morphology of the artery, size of the aneurysm, and form. A correlation existed between the mean WSS on the aneurysmal sac for lateral unruptured and ruptured aneurysms with an aneurysm surface index, which is defined as the ratio between the aneurysm area and the artery area at model inlet, respectively. (C) 2007 IPEM. Published by Elsevier Ltd. All rights reserved.