Quantification with a dedicated breast PET/CT scanner
Quantification with a dedicated breast PET/CT scanner
复制标题
DOI：
10.1118/1.3703593
复制
发表时间：
2012-05-01
期刊：
影响因子：
3.8
通讯作者：
Badawi, Ramsey D.
中科院分区：
文献类型：
--
作者：
Bowen, Spencer L.;Ferrero, Andrea;Badawi, Ramsey D.
目的：专用的乳腺PET/CT有望在乳腺癌的局部分期、手术计划、治疗反应监测和残留病变检测中发挥作用。定量指标将是不可或缺的几个这样的应用程序。作者提出了一个自定义构建的专用乳腺PET/CT（DbPET/CT）扫描仪通过F-18-FDG体模scannes.Methods的全三维数据校正方案的验证：一个组件为基础的标准化实施，生存时间估计与多组分模型，方差减少随机估计计算延迟的巧合。通过使用基于CT的分割方案计算衰减因子，同时使用蒙特卡罗（MC）模拟方法计算散射。由于乳腺PET系统目前没有性能标准，因此根据之前的患者成像结果创建了自定义性能测试。计数率线性的生存时间和随机校正测量与衰减实验的固体聚乙烯圆柱体模与偏移线源。MC模拟用于验证衰减校正，具有不对称活性分布的多室体模提供了散射校正的评估，并且从均匀圆柱体模的高计数扫描测量几何和探测器归一化后的图像均匀性。原始数据在傅立叶重组后用滤波反投影（FBP）重建。为了量化性能的绝对活性浓度，对比度恢复系数和图像的均匀性计算通过区域的利益analysis.Results：最显着的错误来源是由于堆积的事件错位，提出在计数相关的轴向和transaxial不均匀性，没有纠正与这里使用的归一化方法。在临床试验期间观察到的单个计数范围内，应用所有校正后的剩余误差与商用全身PET/CT系统相当。结论：结果表明，DbPET/CT能够在患者成像期间预期的操作条件下产生定量图像。(C)2012年美国医学物理学家协会。[http：//dx.doi.org/10.1118/1.3703593]
Purpose: Dedicated breast PET/CT is expected to have utility in local staging, surgical planning, monitoring of therapy response, and detection of residual disease for breast cancer. Quantitative metrics will be integral to several such applications. The authors present a validation of fully 3D data correction schemes for a custom built dedicated breast PET/CT (DbPET/CT) scanner via F-18-FDG phantom scans.Methods: A component-based normalization was implemented, live-time was estimated with a multicomponent model, and a variance reduced randoms estimate was computed from delayed coincidences. Attenuation factors were calculated by using a CT based segmentation scheme while scatter was computed using a Monte Carlo (MC) simulation method. As no performance standard currently exists for breast PET systems, custom performance tests were created based on prior patient imaging results. Count-rate linearity for live-time and randoms corrections was measured with a decay experiment for a solid polyethylene cylinder phantom with an offset line source. A MC simulation was used to validate attenuation correction, a multicompartment phantom with asymmetric activity distribution provided an assessment of scatter correction, and image uniformity after geometric and detector normalization was measured from a high count scan of a uniform cylinder phantom. Raw data were reconstructed with filtered back projection (FBP) after Fourier rebinning. To quantify performance absolute activity concentrations, contrast recovery coefficients and image uniformity were calculated through region of interest analysis.Results: The most significant source of error was attributed to mispositioning of events due to pileup, presenting in count-related axial and transaxial nonuniformities that were not corrected for with the normalization method used here. Within the range of singles counts observed during clinical trials residual error after applying all corrections was comparable to that of a commercial whole body PET/CT system.Conclusions: The results suggest that DbPET/CT is capable of producing quantitative images under the operating conditions expected during patient imaging. (C) 2012 American Association of Physicists in Medicine. [http://dx.doi.org/10.1118/1.3703593]