Effect of Age of Infusion Site and Type of Rapid-Acting Analog on Pharmacodynamic Parameters of Insulin Boluses in Youth With Type 1 Diabetes Receiving Insulin Pump Therapy
Effect of Age of Infusion Site and Type of Rapid-Acting Analog on Pharmacodynamic Parameters of Insulin Boluses in Youth With Type 1 Diabetes Receiving Insulin Pump Therapy
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DOI：
10.2337/dc08-0595
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发表时间：
2009-02-01
期刊：
影响因子：
16.2
通讯作者：
Weinzimer, Stuart A.
中科院分区：
文献类型：
--
作者：
Swan, Karena L.;Dziura, James D.;Weinzimer, Stuart A.
目的-本研究的目的是检查胰岛素类似物的类型和插入部位的年龄对接受胰岛素泵治疗的1型糖尿病青少年的标准胰岛素推注的药效学特征的影响。研究设计和方法-17名接受胰岛素泵治疗的1型糖尿病青少年在接受0.2单位/小时的胰岛素泵治疗后接受了两次正葡萄糖钳夹手术。第1天门冬胰岛素或赖脯胰岛素（kg）推注，第4天插入胰岛素泵部位。葡萄糖输注率（GIR）所需的维持euglycin是主要的药效学measure.RESULTS-有没有任何统计学上的显着差异，在第1天和第4天之间的任何药效学参数门冬胰岛素和赖脯氨酸。然而，当两组合并时，与第1天相比，第4天观察到的停止外源性葡萄糖输注的时间和胰岛素作用的半数最大起效和抵消时间显著提前（P = 0.03-0.0004），但第1天和第4天GIR曲线下总面积相似。结论-门冬胰岛素和赖脯胰岛素，随着输注部位使用持续时间的增加，作用峰值提前，作用持续时间缩短，但总体胰岛素作用不受影响。
OBJECTIVE - The purpose of this study was to examine the effect of type of insulin analog and age of insertion site on the pharmacodynamic characteristics of a standard insulin bolus in youth with type 1 diabetes receiving insulin pump therapy.RESEARCH DESIGN AND METHODS - Seventeen insulin pump-treated adolescents with type 1 diabetes underwent two euglycemic clamp procedures after a 0.2 unit/kg bolus of either insulin aspart or lispro on day 1 and clay 4 of insulin pump site insertion. The glucose infusion rate (GIR) required to maintain euglycemia was the primary pharmacodynamic measure.RESULTS- There were no statistically significant differences in any of the pharmacodynamic parameters between aspart and lispro during day 1 and day 4. However, when the two groups were combined, time to discontinuation of exogenous glucose infusion, and time to half-maximal onset and offset of insulin action were observed significantly earlier during day 4 compared with day 1 (P = 0.03-0.0004), but the overall area under the GIR curve was similar on day 1 and day 4.CONCLUSIONS - With both insulin aspart and lispro, there is an earlier peak and shorter duration of action with increasing duration of infusion site use, but overall insulin action is not affected.