Clinicopathological analysis and prognostic significance of programmed cell death-ligand 1 protein and mRNA expression in non-small cell lung cancer.
Clinicopathological analysis and prognostic significance of programmed cell death-ligand 1 protein and mRNA expression in non-small cell lung cancer.
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DOI：
10.1371/journal.pone.0198634
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Chung JH
中科院分区：
文献类型：
--
作者：
Kim H;Kwon HJ;Park SY;Park Y;Park E;Chung JH
In this study, we present the clinicopathological features associated with PD-L1 protein and mRNA expression in a large Asian cohort of patients with non-small cell lung cancer (NSCLC) and assessed the prognostic implications of PD-L1 expression, particularly in early stage NSCLC. We retrospectively analyzed 687 NSCLC specimens (476 adenocarcinoma and 211 squamous cell carcinoma) using tissue microarray. PD-L1 immunohistochemistry (IHC) was performed using Dako 22C3 pharmDx assay and PDL1 mRNA was measured using RNA in situ hybridization (RISH). The overall prevalence of PD-L1 protein expression was 25.2% in tumor cells and PDL1 mRNA expression was 11.9%. There was a strong positive correlation between PD-L1 IHC and RISH results (Spearman’s rho = 0.6, p<0.001). In adenocarcinoma, PD-L1 protein and mRNA expressions significantly correlated with poorly differentiated histologic subtype (p<0.001 and p = 0.002, respectively). PD-L1 expression was also associated with genetic alteration in adenocarcinoma. High PD-L1 expression level was associated with EGFR-naïve and KRAS-mutant subgroup (p = 0.001 and p = 0.017, respectively). With a 1% cut-off value, PD-L1 protein expression showed a short overall survival duration in early stage adenocarcinoma with marginal significance (p = 0.05, Hazard ratio = 1.947). Our study revealed that PD-L1 expression varied with histologic subtype and genomic alteration status in lung adenocarcinoma, and activation of the PD-L1 pathway may be a poor prognostic factor especially in early stage lung adenocarcinoma. In addition, PDL1 RISH showed promising results in predicting PD-L1 protein expression in NSCLC.
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影响因子：
50.5
作者：
Ilie, M.;Long-Mira, E.;Hofman, P.
通讯作者：
Hofman, P.
影响因子：
20.4
作者：
Sun, Jong-Mu;Zhou, Wei;Kim, Jhingook
通讯作者：
Kim, Jhingook
影响因子：
2.5
作者：
Pan, Zhen-Kui;Ye, Feng;Wu, Jing-Xun
通讯作者：
Wu, Jing-Xun
影响因子：
20.4
作者：
Hirsch, Fred R.;McElhinny, Abigail;Kerr, Keith M.
通讯作者：
Kerr, Keith M.
17β-雌二醇通过ERα阳性癌细胞系中PI3K/AKT信号通路对PD-L1表达的转录后控制。
DOI：
10.1097/igc.0000000000000875
发表时间：
2017-02
期刊：
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
影响因子：
--
作者：
Yang L;Huang F;Mei J;Wang X;Zhang Q;Wang H;Xi M;You Z
通讯作者：
You Z