Cardiac Hegemony of Senescence.
Cardiac Hegemony of Senescence.
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衰老的心脏霸权。
DOI：
10.1007/s13670-013-0064-3
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Sussman, Mark A
中科院分区：
文献类型：
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作者：
Siddiqi, Sailay;Sussman, Mark A
在过去的几十年里，由于医疗保健的可及性和质量的提高，心脏衰老和与年龄相关的疾病的发展得到了普遍的关注和认可。全球文明的进步是对人口老龄化和慢性退行性疾病发展的关切的补充。心脏退行性变已经得到了严格的研究。心脏衰老的分子机制在多个细胞水平上，并且具有多层复杂性，因此阻碍了明确的治疗方案的发展。特别是，通过衰老分泌体在心肌细胞和干细胞之间的衰老表型的协同交换显得复杂，具有很大的未来治疗价值。目前的综述文章将重点介绍衰老、心肌细胞和干细胞衰老的特征，以及衰老分泌体的相互交换。未来的心肌细胞治疗方法需要对心肌衰老有全面的了解，以提高治疗效率和疗效。
Cardiac senescence and age-related disease development have gained general attention and recognition in the past decades due to increased accessibility and quality of health care. The advancement in global civilization is complementary to concerns regarding population aging and development of chronic degenerative diseases. Cardiac degeneration has been rigorously studied. The molecular mechanisms of cardiac senescence are on multiple cellular levels and hold a multilayer complexity level, thereby hampering development of unambiguous treatment protocols. In particular, the synergistic exchange of the senescence phenotype through a senescence secretome between myocytes and stem cells appears complicated and is of great future therapeutic value. The current review article will highlight hallmarks of senescence, cardiac myocyte and stem cell senescence, and the mutual exchange of senescent secretome. Future cardiac cell therapy approaches require a comprehensive understanding of myocardial senescence to improve therapeutic efficiency as well as efficacy.