Application of Hyperthermia Using Dextran Magnetite Complex (DM) for Head and Neck Cancer
Application of Hyperthermia Using Dextran Magnetite Complex (DM) for Head and Neck Cancer
复制标题
右旋糖酐磁铁矿复合物（DM）热疗在头颈癌中的应用
DOI：
10.3191/thermalmedicine.14.197
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
H. Nagae
中科院分区：
文献类型：
--
作者：
S. Wada;K. Tazawa;I. Furuta;S. Takemori;T. Minamimura;H. Nagae
本研究的目的是阐明右旋糖酐磁铁矿复合物（DM）用于头颈部的可能性。DM是亚结构域颗粒的胶体悬浮液。众所周知，二甲基甲酰胺在交变磁场下能有效地利用其物理化学特性产生热量。在我们的研究中，DM注射到不同铁浓度的金黄地鼠的正常舌中，舌被500 kHz的交流磁场加热。在112、56和42 mg/ml的不同铁浓度下，舌温分别在60、120和570秒的时间点达到约43 ℃。然而，在铁浓度为28 mg/ml时，尽管加热660秒，也没有获得所需的温度。在最佳铁离子浓度为56 mg/ml时，通过改变交流磁场强度进行了温度维持研究。注射DM的舌温可维持在43 ℃左右30分钟。对于该加热期，未注射DM的对侧舌轻微加热至约34.5 ℃，直肠温度保持在约31.0 ℃。在加热研究之后，检查DM的放射学和组织学分布。X线平片上半舌侧可见均匀的DM影。HE染色显示DM在肌纤维间的结缔组织中聚集。我们相信，这种热系统可能是有用的头颈部癌症的治疗。
The purpose of this hyperthermic study was to clarify to the possibility of dextren magnetite complex (DM) for the head and neck region. DM is a colloidal suspension of subdomain particles. It is known that DM efficiently genarates the heat under alternating current (AC) magnetic field by its physio-chemical characteristics . In our study, DM were injected into the normal tongue of golden hamsters at various iron concentrations and the tongue was heated by 500 kHz AC magnetic field. At the different iron concentrations of 112 , 56, and 42mg/ml, the tongue temperature reached to approximately 43•Ž at the time points of 60 ,120,and 570 seconds respectively. Nevertheless, at an iron concentration of 28 mg/ml , the desireable temperrature was not obtained in spite of heating for 660 seconds. Furthermore, at the optimum iron concentration of 56mg/ml , the temperature maintenance study was performed by changing the AC magnetic field strength . The temperature of DM injected tongue could be maintained at approximately 43•Ž for 30 minutes. For this heating period , the contralateral tongue into which DM was not injected was slightly heated up to approximately 34.5•Ž and the rectal temperature had been kept at approximately 31.0•Ž. After the heating study, the radiographic and histological distributions of DM were examined. In radiographic image, the homogenous shadow of DM were obserbed in the half side of the tongue . HE staining demonstrated that the accumulation of DM was seen in the connective tissue between the musclar fibers. We believe that this hyperthermic system may be useful for head and neck cancer therapy .