DETERMINATION OF IRRITANCY POTENTIAL OF SURFACTANTS USING VARIOUS METHODS OF ASSESSMENT
DETERMINATION OF IRRITANCY POTENTIAL OF SURFACTANTS USING VARIOUS METHODS OF ASSESSMENT
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DOI：
10.3109/01480547809105022
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发表时间：
1978-01-01
影响因子：
2.6
通讯作者：
DODD, KT
中科院分区：
文献类型：
--
作者：
CIUCHTA, HP;DODD, KT
评价了几种动物刺激性试验方法，其标准包括感觉反应、疼痛/不适或组织损伤，以评估以下表面活性剂的相对刺激性潜力：十二烷基聚醚（12）硫酸钠（SLES）、Miranol C2M（MC 2 M）、Miranol MHT（MMHT）、椰油甲基牛磺酸钠（SCMT）、十二烷基硫酸三乙醇胺（TEALS）、十二烷基硫酸铵（ALS）和十二烷基硫酸钠（SLS）。小鼠上呼吸道和扭体实验结果表明，SLES、MC 2 M和MMHT的刺激性最小，SLS、ALS和TEALS的刺激性最大。眼睑痉挛试验本身不适合这种类型的评价，因为连续滴注表面活性剂产生眼麻醉。Draize眼部试验的数据表明，SLES的刺激性最小，而MC 2 M的刺激性略强。所有其他表面活性剂都具有同样的刺激性。Draize皮肤测试结果显示，在所有测试浓度下，SLES的刺激性最小，而SLS和ALS以及TEALS和SCMT的刺激性最大，沿着。
Several animal irritancy test methods whose criteria included sensory response, pain/discomfort or tissue damage were evaluated to assess relative irritancy potential of the following surfactants: sodium lauryl polyether (12) sulfate (SLES), Miranol C2M (MC2M), Miranol MHT (MMHT), sodium coco methyl tauride (SCMT), triethanolamine lauryl sulfate (TEALS), ammonium lauryl sulfate (ALS) and sodium lauryl sulfate (SLS). Data from the mouse upper respiratory tract and mouse writhing tests indicated that SLES, MC2M and MMHT were the least irritating and SLS, ALS and TEALS were the most irritating. The blepharospasm test did not lend itself to this type of evaluation because sequential instillation of the surfactants produced eye anesthesia. Data from the Draize eye test indicated that SLES was the least irritating while MC2M was slightly more irritating. All other surfactants were equally irritating. The Draize skin test results showed that SLES was the least irritating at all concentrations tested and that SLS and ALS along with TEALS and SCMT were the most irritating.