Mortalin is a prognostic factor of gastric cancer with normal p53 function
Mortalin is a prognostic factor of gastric cancer with normal p53 function
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DOI：
10.1007/s10120-013-0279-1
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发表时间：
2014-04-01
期刊：
影响因子：
7.4
通讯作者：
Maehara, Yoshihiko
中科院分区：
文献类型：
--
作者：
Ando, Koji;Oki, Eiji;Maehara, Yoshihiko
死亡蛋白是热休克蛋白70家族中的一个非热诱导的成员。Mortalin与p53结合并阻止p53进入细胞核。为探讨mortalin在胃癌中的意义，我们采用免疫组化方法检测了182例胃癌组织中mortalin和p53的表达，结果显示，mortalin阳性和p53异常阳性的胃癌分别占75.2%和49.5%。Mortalin阳性组与阴性组相比，肿瘤浸润深度、淋巴结转移和肝转移明显增加（P < 0.01，P < 0.05）。Mortalin阳性组预后差于Mortalin阴性组（P = 0.035）。在p53功能正常的胃癌中，mortalin表达阳性的胃癌预后差于mortalin表达阴性的胃癌（P = 0.017），Mortalin对p53功能正常的胃癌预后影响较大。因此，mortalin是治疗胃癌的靶分子，也是一个有希望的预后因子，特别是在p53正常的肿瘤中。
Mortalin is a heat-non-inducible member of the heat shock protein 70 family. Mortalin binds to p53 and prevents p53 from entering the nucleus. To understand the significance of mortalin in gastric cancer, we investigated the expression of mortalin and p53.Expression of mortalin and p53 was examined by immunohistochemical staining of 182 clinical samples of gastric cancer.Mortalin-positive and aberrant p53-positive tumors were found in 75.2 and 49.5 % of cases, respectively. Mortalin-positive tumors were deeper in invasion and had more lymph node and liver metastases compared with mortalin-negative tumors (P < 0.01, P < 0.05, respectively). Mortalin-positive tumors had worse prognosis compared with mortalin-negative tumors (P = 0.035). Moreover, in tumors with normal p53 function, mortalin-positive tumors had worse prognosis compared with mortalin-negative tumors (P = 0.017).Mortalin has a great impact on gastric cancer with normal p53. Therefore, mortalin is a target molecule for treatment of gastric cancer, as well as a promising prognostic factor, especially in tumors with normal p53.