Clinicopathological evaluation of carcinoma cuniculatum: a variant of oral squamous cell carcinoma
Clinicopathological evaluation of carcinoma cuniculatum: a variant of oral squamous cell carcinoma
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DOI：
10.1111/j.1600-0714.2011.01116.x
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发表时间：
2012-04-01
影响因子：
3.3
通讯作者：
Yamamoto, Hirotsugu
中科院分区：
文献类型：
--
作者：
Sun, Yan;Kuyama, Kayo;Yamamoto, Hirotsugu
楔状癌是一种罕见的口腔鳞状细胞癌，由于其发病率低和独特的结构，一直是病理学家面临的组织病理学挑战。因此，本研究的目的是阐明这种独特的病变的临床病理学表现和生物学行为。从病历中检索临床和随访信息，并进行组织病理学分析。我们的系列包括15例CC，研究包括7名男性和8名女性，年龄44-92岁。舌和下颌骨是最常见的受影响部位。有3例淋巴结转移，3例局部复发，其中1例死于口腔癌肺转移。组织学上，与其他亚型的口腔鳞状细胞癌的鉴别诊断点包括独特的，楔状结构和分支隐窝。由于其高分化状态，CC的预后通常是乐观的。然而，在我们的研究中，复发病例可能具有传统治疗无法很好控制的侵袭性生物学特征;在一例病例中，部分CC转化为传统鳞状细胞癌（SCC）。这可能表明应进一步强调转化CC而不是原发CC。口腔病理医学杂志（2012）41：303-308
Carcinoma cuniculatum (CC) is a rare neoplasm of oral squamous cell carcinoma (OSCC) and remains a histopathological challenge to pathologists because of its low incidence and unique architecture. Therefore, the purpose of this study was to illustrate the clinicopathological findings and biological behavior about this distinctive lesion. Clinical and follow-up information were retrieved from medical charts, and histopathological analyses were performed. Our series included 15 cases of CC, and the study included seven men and eight women, age 44-92. The tongue and mandible were the most frequently affected sites. There were three lymph node metastasis cases, and three local recurrences; one of the patients died of lung metastasis from oral CC. Histopathologically, the point of differential diagnosis with other subtypes of OSCC included unique, cuniculatum architecture and branching crypts. Because of its well-differentiated status, the prognosis of CC is usually optimistic. However, recurrent cases in our study might have possessed invasive biological characters that were not well controlled by conventional treatment; in one case, a portion of the CC transformed into conventional squamous cell carcinoma (SCC). This might suggest that transformed CC rather than primary CC should be further emphasized. J Oral Pathol Med (2012) 41: 303-308