Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress.
Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress.
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DOI：
10.1016/j.freeradbiomed.2012.11.010
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发表时间：
2013-03
影响因子：
7.4
通讯作者：
Vasiliou, Vasilis
中科院分区：
文献类型：
--
作者：
Singh, Surendra;Brocker, Chad;Koppaka, Vindhya;Chen, Ying;Jackson, Brian C.;Matsumoto, Akiko;Thompson, David C.;Vasiliou, Vasilis
关键词：
Reactive oxygen species (ROS) are continuously generated within living systems and the inability to manage ROS load leads to elevated oxidative stress and cell damage. Oxidative stress is coupled to the oxidative degradation of lipid membranes, also known as lipid peroxidation. This process generates over 200 types of aldehydes, many of which are highly reactive and toxic. Aldehyde dehydrogenases (ALDHs) metabolize endogenous and exogenous aldehydes and thereby mitigate oxidative/electrophilic stress in prokaryotic and eukaryotic organisms. ALDHs are found throughout the evolutionary gamut, from single celled organisms to complex multicellular species. Not surprisingly, many ALDHs in evolutionarily distant, and seemingly unrelated, species perform similar functions, including protection against a variety of environmental stressors like dehydration and ultraviolet radiation. The ability to act as an ‘aldehyde scavenger’ during lipid peroxidation is another ostensibly universal ALDH function found across species. Up-regulation of ALDHs is a stress response in bacteria (environmental and chemical stress), plants (dehydration, salinity and oxidative stress), yeast (ethanol exposure and oxidative stress), Caenorhabditis elegans (lipid peroxidation) and mammals (oxidative stress and lipid peroxidation). Recent studies have also identified ALDH activity as an important feature of cancer stem cells. In these cells, ALDH expression helps abrogate oxidative stress and imparts resistance against chemotherapeutic agents such as oxazaphosphorine, taxane and platinum drugs. The ALDH superfamily represents a fundamentally important class of enzymes that significantly contributes to the management of electrophilic/oxidative stress within living systems. Mutations in various ALDHs are associated with a variety of pathological conditions in humans, underscoring the fundamental importance of these enzymes in physiological and pathological processes.
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ALDH3A1介导的细胞保护针对4-羟基-2-非纳尔的分子机制。
影响因子：
7.4
作者：
Black, William;Chen, Ying;Matsumoto, Akiko;Thompson, David C.;Lassen, Natalie;Pappa, Aglaia;Vasiliou, Vasilis
通讯作者：
Vasiliou, Vasilis
影响因子：
2.9
作者：
BERGMANSON, JPG;SODERBERG, PG
通讯作者：
SODERBERG, PG
影响因子：
6.8
作者：
Achary, V. Mohan Murali;Jena, Suprava;Panda, Brahma B.
通讯作者：
Panda, Brahma B.
影响因子：
2.3
作者：
Brooks, PJ;Theruvathu, JA
通讯作者：
Theruvathu, JA
DOI：
10.1111/j.1530-0277.1987.tb00167.x
发表时间：
1987-12-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
AMBROZIAK, W;PIETRUSZKO, R
通讯作者：
PIETRUSZKO, R