Antibacterial activity of pure flavonoids isolated from mosses
Antibacterial activity of pure flavonoids isolated from mosses
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DOI：
10.1016/s0031-9422(99)00286-1
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发表时间：
1999-12-01
期刊：
影响因子：
3.8
通讯作者：
Cobianchi, RC
中科院分区：
文献类型：
--
作者：
Basile, A;Giordano, S;Cobianchi, RC
从五种苔藓中分离并鉴定出七种纯黄酮类化合物。黄酮类化合物为黄酮芹菜素、芹菜素-7-O-三糖苷、lucenin-2、木犀草素-7-O-新橙皮苷、皂苷和牡荆素；和双黄酮类bartramiaflavone。其中一些黄酮类化合物被证明对阴沟肠杆菌、产气肠杆菌和铜绿假单胞菌具有显着的抗菌作用（最低抑菌浓度MIC在4-2048μg/ml范围内）。由于它们的抗菌谱主要针对革兰氏阴性细菌菌株，导致严重的机会性感染并对常见的抗菌治疗产生耐药性，因此这些黄酮类化合物可能是抗菌策略的重要工具。 (C) 1999 Elsevier Science Ltd. 保留所有权利。
Seven pure flavonoids were isolated and identified from five moss species. The flavonoids were the flavones apigenin, apigenin-7-O-triglycoside, lucenin-2, luteolin-7-O-neohesperidoside, saponarine and vitexin; and the biflavonoid bartramiaflavone. Some of these flavonoids were shown to have pronounced antibacterial effects against Enterobacter cloaceae, E. aerogenes and Pseudomonas aeruginosa (minimal bacteriostatic concentration MIC in the range of 4-2048 mu g/ml). Because of their antibacterial spectrum mainly active against Gram negative bacterial strains, responsible for severe opportunistic infections and resistant to common antibacterial therapy, these flavonoids may be important tools in antibacterial strategies. (C) 1999 Elsevier Science Ltd. All rights reserved.