Racemization-free synthesis of S-alkylated cysteines via thiol-ene reaction
Racemization-free synthesis of S-alkylated cysteines via thiol-ene reaction
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DOI：
10.1021/jo800198s
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发表时间：
2008-05-02
影响因子：
3.6
通讯作者：
Waldmann, Herbert
中科院分区：
文献类型：
--
作者：
Triola, Gemma;Brunsveld, Luc;Waldmann, Herbert
[GRPAHICS]在自由基引发剂（AIBN）的存在下，用不同的烯烃处理不同的受保护和未受保护的半胱氨酸，可得到相应的s -烷基化半胱氨酸，产率高且不发生外消旋。
[GRPAHICS]Treatment of differently protected and unprotected cysteines with a variety of alkenes in the presence of a radical initiator (AIBN) afforded the corresponding S-alkylated cysteines in high yields and without racemization.