The neural crest
The neural crest
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DOI：
10.1242/dev.091751
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发表时间：
2013-06-01
期刊：
影响因子：
4.6
通讯作者：
Theveneau, Eric
中科院分区：
文献类型：
--
作者：
Mayor, Roberto;Theveneau, Eric
神经嵴（NC）是一种高度迁移的多能细胞群，形成于发育胚胎的神经上皮和预期表皮之间的界面。在整个胚胎中广泛迁移后，NC细胞最终定居以分化成多种细胞类型，范围从周围神经系统的神经元和神经胶质细胞到色素细胞，成纤维细胞到平滑肌细胞，以及成牙本质细胞到脂肪细胞。NC细胞大量迁移，其迁移受多种机制调节，包括趋化性、运动的接触抑制和细胞分选。在这里，我们提供了一个概述NC的形成，分化和迁移，突出NC迁移的分子机制。
The neural crest (NC) is a highly migratory multipotent cell population that forms at the interface between the neuroepithelium and the prospective epidermis of a developing embryo. Following extensive migration throughout the embryo, NC cells eventually settle to differentiate into multiple cell types, ranging from neurons and glial cells of the peripheral nervous system to pigment cells, fibroblasts to smooth muscle cells, and odontoblasts to adipocytes. NC cells migrate in large numbers and their migration is regulated by multiple mechanisms, including chemotaxis, contact-inhibition of locomotion and cell sorting. Here, we provide an overview of NC formation, differentiation and migration, highlighting the molecular mechanisms governing NC migration.