Can Trophoblast Be Killed by Cytotoxic Cells?: In Vitro Evidence and in Vivo Possibilities
Can Trophoblast Be Killed by Cytotoxic Cells?: In Vitro Evidence and in Vivo Possibilities
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滋养层细胞可以被细胞毒性细胞杀死吗？：体外证据和体内可能性
DOI：
10.1111/j.1600-0897.1989.tb00647.x
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发表时间：
1989
影响因子：
3.6
通讯作者：
J. Head
中科院分区：
文献类型：
--
作者：
J. Head
It ha.s been decades since the important concept was formahzed that the placenta may represent an immunologically inert buffer, protecting both the fetus and itselffrom destruction by maternal effectors.' Initially, the need for such a mechanism was rationalized by the an8:logy of the fetal-placental unit to an allograft gen~~1cally ~apable ~f expressing paternal histocompatibility antigens, WIth the potential for destruction by maternal alloantibodies or allospecific cytotoxic T lymphocytes (CTL).2 The focus of attention was quite naturally the trophoblast cells, the frontier fetal-derived cells at the maternal-fetal interface. Two key questions central to this issue were, 1) are the relevant antigens expressed on trophoblast cells? and 2) if so, are trophoblast cells susceptible to lysis by allospecific effectors? With the discoveries of several other cytotoxic cells such as those mediating various forms of natural, non~ MHC-restricted cytotoxicity, the questions have been expanded to include these cytotoxic effectors as well.
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Pa 和 RT1.Aa 抗原在大鼠胎盘和胎儿组织上表达的个体发育。
DOI：
10.1111/j.1600-0897.1987.tb00091.x
发表时间：
1987
期刊：
American journal of reproductive immunology and microbiology : AJRIM
影响因子：
--
作者：
Ho,HN;Macpherson,TA;Kunz,HW;Gill3rd,TJ
通讯作者：
Gill3rd,TJ
MHC 抗原在小鼠滋养层上的表达及其受干扰素的调节。
DOI：
--
发表时间：
1986
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Zuckermann,FA;Head,JR
通讯作者：
Head,JR
影响因子：
3.8
作者：
Zuckermann,FA;Head,JR
通讯作者：
Head,JR
DOI：
--
发表时间：
1985
期刊：
The American journal of pathology
影响因子：
--
作者：
Kabawat,SE;Mostoufi-Zadeh,M;Driscoll,SG;Bhan,AK
通讯作者：
Bhan,AK
小鼠滋养层可抵抗细胞介导的裂解。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Zuckermann,FA;Head,JR
通讯作者：
Head,JR