Interaction between beta-3 adrenergic receptor genotype and environmental factors on periodontal progression
Interaction between beta-3 adrenergic receptor genotype and environmental factors on periodontal progression
复制标题
β3肾上腺素受体基因型与环境因素对牙周进展的相互作用
DOI：
10.1111/jcpe.13115
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发表时间：
2019
影响因子：
6.7
通讯作者：
Iwasaki M
中科院分区：
文献类型：
--
作者：
Yoshihara A;Kaneko N;Nohno K;Iwasaki M
ObjectivesThe的目的是评估β-3肾上腺素能受体多态性和环境因素之间的关系，如吸烟对牙周病的影响modification.Materials and MethodsA共294名受试者参加了所有的后续调查，在6年的研究期间进行了分析。根据吸烟年数将受试者分为三分位后，我们进行了泊松回归分析，以比较6年研究期间牙周病事件的发病率比（IRR）与β 3肾上腺素能受体基因型之间的差异。（1：Arg等位基因携带者，2：Arg等位基因非携带者）的每个三分位数调整其他四个变量。第1、2和3个三分位数的平均值±标准差分别为0 ± 0、20.1 ± 9.1和45.3 ± 7.7年。IRR ± SE为0.89 ± 0.08（p= 0.218）对于第一个三分位数，1.93 ± 0.36（p< 0.001）第二个三分位数和2.56 ± 0.23（p< 0.001）的第三个三分位数。基于吸烟年数的β-3肾上腺素能受体基因型与牙周病进展之间的反应关系。
ObjectivesThe purpose of this longitudinal study was to evaluate the relationship between beta‐3 adrenergic receptor polymorphism and environmental factors such as smoking on periodontal disease by considering effect modification.Materials and MethodsA total of 294 subjects who participated in all follow‐up surveys over the 6‐year study period were analysed. After dividing subjects into tertiles according to the number of years exposed to smoking, we conducted Poisson regression analysis to compare the incidence rate ratio (IRR) for periodontal disease events during the 6‐year study period with beta‐3 adrenergic receptor genotype (1: Arg allele carriers, 2: Arg allele non‐carriers) for each tertile adjusted for other four variables.ResultsThe number of years exposed to smoking (mean ± standard deviation) for the 1st, 2nd and 3rd tertiles was 0 ± 0, 20.1 ± 9.1 and 45.3 ± 7.7 years, respectively. The IRRs ±SEwere 0.89 ± 0.08 (p= 0.218) for the 1st tertile, 1.93 ± 0.36 (p< 0.001) for the 2nd tertile and 2.56 ± 0.23 (p< 0.001) for the 3rd tertile.ConclusionThere was a clear dose–response relationship between beta‐3 adrenergic receptor genotype and periodontal disease progression based on the number of years exposed to smoking.