Metallobiology of Tuberculosis.
Metallobiology of Tuberculosis.
复制标题
结核病金属生物学。
DOI：
10.1128/microbiolspec.mgm2-0012-2013
复制
发表时间：
2014
影响因子：
3.7
通讯作者：
Neyrolles,Olivier
中科院分区：
文献类型：
--
作者：
MarcelaRodriguez,G;Neyrolles,Olivier
Iron is absolutely required for the life of most organisms, including mycobacteria. Iron is incorporated into proteins, either as a mono‐ or binuclear species or as part of heme groups or iron‐sulfur clusters. Iron undergoes reversible changes in its oxidation state, oscillating between the oxidized ferric (Fe3+) and the reduced ferrous (Fe2+) forms. In addition, depending on the local ligand environment, iron‐containing compounds exhibit a wide range of oxidation‐reduction potentials. These unique properties make this metal a very versatile prosthetic component as a biocatalyst and electro‐carrier in essential cellular pathways including respiration, the trichloroacetic acid (TCA) cycle, oxygen transport, gene regulation, defense against oxidative stress, and DNA biosynthesis (1).
