Composition of Faecal Microbiota and Metabolism of Faecal Bacteria of Pig-Flora-Associated (PFA) mice
Composition of Faecal Microbiota and Metabolism of Faecal Bacteria of Pig-Flora-Associated (PFA) mice
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猪菌群相关 (PFA) 小鼠粪便微生物群的组成和粪便细菌的代谢
DOI：
10.3402/mehd.v9i5.8372
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发表时间：
1996
影响因子：
--
通讯作者：
T. Sawasaki
中科院分区：
文献类型：
--
作者：
K. Hirayama;K. Itoh;E. Takahashi;K. Shinozaki;T. Sawasaki
在断奶前后接种猪粪便悬浮液的猪菌群相关（PFA）小鼠中，研究了其粪便微生物群的组成以及粪便短链脂肪酸（SCFA）和腐败产物的浓度。猪的主要粪便细菌定植于PFA小鼠的肠道，并且PFA小鼠粪便的微生物组成与猪粪便接种物相似。出乎意料的是，猪粪便中的乳酸杆菌也以10 6 -10 9 /g粪便的水平定植于PFA小鼠组的肠道中。然而，尽管 PFA 小鼠 SCFA 主要成分的浓度与接种物相似，但 PFA 小鼠粪便中腐败产物的浓度与接种物中的浓度并不相似。这些发现表明，PFA 小鼠是研究猪粪便微生物群生态系统和猪肠道 SCFA 控制的良好模型，但不适用于研究猪肠道中产生的腐败产物。关键词：猪菌群相关小鼠、粪便微生物群、腐败产物、短链脂肪酸。
The composition of the faecal microbiota and concentrations of faecal short chain fatty acids (SCFAs) and putrefactive products were studied in pig-flora-associated (PFA) mice inoculated with faecal suspensions from pigs before and after weaning. Major faecal bacteria of pigs colonised the intestine of PFA mice, and the composition of microbiota of the PFA mouse faeces were similar to that of the pig faeces inoculum. Unexpectedly, pig faecal lactobacilli also colonised the intestines of PFA mouse groups at levels of 10 6 -10 9 /g faeces. However, faecal concentrations of putrefactive products in PFA mice did not simulate those in the inocula, although the concentrations of the major components of SCFAs of PFA mice were similar to those of the inocula. These findings indicate that PFA mice are a good model for studying the ecosystem of pig faecal microbiota and the control of SCFAs in the pig intestine, but not for studying putrefactive products generated in the pig intestine. Keywords: pig-flora-associated mice, faecal microbiota, putrefactive products, short chain fatty acids.