Interplay between renal endothelin and purinergic signaling systems.
Interplay between renal endothelin and purinergic signaling systems.
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DOI：
10.1152/ajprenal.00639.2016
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发表时间：
2017-02
期刊：
影响因子：
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通讯作者：
Eman Y. Gohar;M. Kasztan;D. Pollock
中科院分区：
文献类型：
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作者：
Eman Y. Gohar;M. Kasztan;D. Pollock
细胞外液容量调节和钠平衡的改变可能导致盐依赖性高血压的发展和维持，这是心血管疾病的主要危险因素。许多途径有助于调节钠排泄和血压，包括内皮素和嘌呤能信号传导。越来越多的证据表明，嘌呤能受体激活和内皮素生产之间的联系，在肾集合管作为一种手段，促进尿钠排泄。更好地了解这两个系统之间的关系，特别是在钠稳态方面，将填补一个显着的知识空白，并可能提供新的抗高血压治疗选择。因此，本文综述了内皮素和嘌呤能信号之间的串扰，因为它涉及到钠和血压稳态的肾脏调节。
Alterations in extracellular fluid volume regulation and sodium balance may result in the development and maintenance of salt-dependent hypertension, a major risk factor for cardiovascular disease. Numerous pathways contribute to the regulation of sodium excretion and blood pressure, including endothelin and purinergic signaling. Increasing evidence suggests a link between purinergic receptor activation and endothelin production within the renal collecting duct as a means of promoting natriuresis. A better understanding of the relationship between these two systems, especially in regard to sodium homeostasis, will fill a significant knowledge gap and may provide novel antihypertensive treatment options. Therefore, this review focuses on the cross talk between endothelin and purinergic signaling as it relates to the renal regulation of sodium and blood pressure homeostasis.