Staging of argyrophilic grains: An age-associated tauopathy
Staging of argyrophilic grains: An age-associated tauopathy
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DOI：
10.1093/jnen/63.9.911
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发表时间：
2004-09-01
影响因子：
3.2
通讯作者：
Murayama, S
中科院分区：
文献类型：
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作者：
Saito, Y;Ruberu, NN;Murayama, S
我们已经报道，周围脑回是嗜银颗粒（AGs）的最大积累的网站和周围脑回的变性是负责与颗粒痴呆。在这里，我们分析了来自两家医院的1,405例连续尸检病例，仅在56岁以上的病例中检测到AG。AG的分布遵循刻板的区域模式。因此，我们提出了以下分期范式：第一阶段：AGs仅限于周围回及其附近;第二阶段：AGs更明显的前，后内侧颞叶，包括颞极，以及下托和内嗅皮层;和第三阶段：丰富的AGs在隔膜，岛叶皮层，前扣带回，伴随海绵变性的周围回。65例（96.9%）无其他痴呆病理的嗜银颗粒III期病例中的63例在临床痴呆评分中被归类为0.5或更高。50例颗粒性痴呆中有47例（94%）为III期，3例为II期。未检测到与apoE基因分型的关联。我们的研究进一步证实，谷物痴呆是一种年龄相关的tau蛋白病，分布相对均匀，可能独立地导致老年人的认知能力下降。
We have reported that the ambient gyrus is the site with the greatest accumulation of argyrophilic grains (AGs) and that the degeneration of the ambient gyrus is responsible for dementia with grains. Here we analyzed 1,405 serial autopsy cases from 2 hospitals and detected AGs only in cases older than 56 years of age. The distribution of AGs followed a stereotypic regional pattern. Thus, we propose the following staging paradigm: stage I: AGs restricted to the ambient gyrus and its vicinity; stage II: AGs more apparent in the anterior and posterior medial temporal lobe, including the temporal pole, as well as the subiculum and entorhinal cortex; and stage III: abundant AGs in the septum, insular cortex, and anterior cingulate gyrus, accompanying spongy degeneration of the ambient gyrus. Sixty-three of 65 (96.9%) argyrophilic grain stage III cases without other dementing pathology were classified as 0.5 or higher in the clinical dementia rating. Forty-seven of 50 dementia with grains cases (94%) were stage III and 3 were stage II. No association with apoE genotyping was detected. Our study further confirms that dementia with grains is an age-associated tauopathy with relatively uniform distribution and may independently contribute to cognitive decline in the elderly.