The Changing Landscape of Renal Inflammation.
The Changing Landscape of Renal Inflammation.
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DOI：
10.1016/j.molmed.2015.12.002
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发表时间：
2016-02
影响因子：
13.6
通讯作者：
Mayadas TN
中科院分区：
文献类型：
--
作者：
Ernandez T;Mayadas TN
肾脏炎症是导致肾小球肾炎和慢性肾脏病的进行性肾损伤的主要原因。在这里，我们回顾了对肾脏中白细胞积累的理解的最新进展，强调了与肾小球肾炎有关的关键趋化因子。我们讨论肾脏炎症的特征，例如免疫细胞可塑性概念的演变。我们还描述了器官特异性组织微环境在塑造免疫细胞反应方面的某些方面，以及调节性 T 淋巴细胞如何影响其他免疫效应细胞群以控制炎症的当前知识。显然，这些领域当前和未来的研究可能有助于新型靶向治疗药物的开发，有望减轻终末期肾病的负担。
Kidney inflammation is a major contributor of progressive renal injury leading to glomerulonephritis and chronic kidney disease. Here, we review recent advances in our understanding of leukocyte accumulation in the kidney, emphasizing critical chemokines involved in glomerulonephritis. We discuss features of renal inflammation such as the evolving concept of immune cell plasticity. We also describe certain aspects of organ-specific tissue microenvironments in shaping immune cell responses, as well as the current knowledge of how regulatory T lymphocytes impact other immune effector cell populations to control inflammation. It is clear that present and future research in these areas may contribute to the development of novel targeted therapeutics, with the hope of alleviating the burden of end-stage renal disease.