Experimental radioimmunotherapy of a xenografted human colonic tumor (GW-39) producing carcinoembryonic antigen.
Experimental radioimmunotherapy of a xenografted human colonic tumor (GW-39) producing carcinoembryonic antigen.
复制标题
产生癌胚抗原的异种移植人结肠肿瘤（GW-39）的实验性放射免疫疗法。
作者：
D. Goldenberg;S. Gaffar;S. Bennett;J. Beach
为评价~(131)I标记的抗癌胚抗原羊抗体免疫球蛋白G对荷GW-39人结肠癌的仓鼠的抗肿瘤作用。单次注射1mCI~(131)I或更高剂量时，可显著抑制GW-39肿瘤的生长，并显著延长荷瘤仓鼠的存活时间。在1mCI剂量下，放射性亲和纯化抗体对肿瘤生长和生存期的影响明显优于放射性正常山羊免疫球蛋白G，而在2mCI剂量下差异不显著。放射生物学计算表明，在治疗后20天，肿瘤接受了132rad的特异性抗体，而只接受了411rad的正常免疫球蛋白G制剂。这些发现鼓励对用于同位素癌症治疗的肿瘤标志物抗体进行进一步评估。
Experiments were undertaken to evaluate the antitumor effects of 131I-labeled goat antibody immunoglobulin G prepared against carcinoembryonic antigen in hamsters bearing the carcinoembryonic antigen-producing GW-39 human colonic carcinoma. At a single injection of 1 mCi 131I and higher, a marked growth inhibition of GW-39 tumors, as well as a considerable increase in the survival time of the tumor-bearing hamsters, could be achieved. At a dose of 1 mCi, the radioactive affinity-purified antibody appeared to be superior to radioactive normal goat immunoglobulin G in influencing tumor growth and survival time, but no significant difference could be seen at the higher dose of 2 mCi given. Radiobiological calculations indicated that the tumors received, at up to 20 days after therapy, 1325 rads for the specific antibody and only 411 rads for the normal immunoglobulin G preparation. These findings encourage the further evaluation of antibodies to tumor markers for isotopic cancer therapy.
针对人类肿瘤抗原的单克隆抗体。
影响因子：
0.9
作者：
Steplewski,Z
通讯作者：
Steplewski,Z