A rat pain model of facial cancer.
A rat pain model of facial cancer.
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DOI：
10.1007/978-1-61779-561-9_10
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发表时间：
2012
影响因子：
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通讯作者：
K. Ono;N. Harano;K. Inenaga;O. Nakanishi
中科院分区：
文献类型：
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作者：
K. Ono;N. Harano;K. Inenaga;O. Nakanishi
对于晚期或晚期癌症患者来说，癌症疼痛是一个非常严重的问题。然而，诱导机制仍然未知。口面部癌症患者经常报告进食和吞咽困难，与其他地区的癌症患者不同。虽然已经报道了几种癌症疼痛动物模型，但这些模型都集中在坐骨神经区域。为了了解口面癌相关疼痛的机制，我们最近通过将癌细胞接种到触须垫中来建立大鼠面部癌模型。该模型提供了类似于口面癌患者的机械异常性疼痛、热痛觉过敏和进食障碍特征。因此，该模型可用于三叉神经区癌痛的评估。在本章中，我们详细描述了通过接种步行者癌肉瘤256 B细胞来产生大鼠面部癌性疼痛模型。
Cancer pain is a very severe problem for patients with advanced or terminal cancer. However, the induction mechanism remains unknown. Orofacial cancer patients often report difficulties in eating and swallowing, different from patients with cancer in other regions. Although several cancer pain animal models have been reported, these models have focused on the sciatic nerve areas. To understand the mechanisms of pain associated with orofacial cancer, we recently created a rat facial cancer model by inoculation of cancer cells into the vibrissal pad. This model provides mechanical allodynia, thermal hyperalgesia, and feeding disorder characteristics, similar to orofacial cancer patients. Hence, this model is useful for the evaluation of cancer pain of the trigeminal nerve area. In this chapter, we describe in detail the generation of a facial cancer pain model of rats by inoculation of Walker carcinosarcoma 256B cells.