A General Catalyst for the β-Selective C-H Bond Arylation of Thiophenes with Iodoarenes
A General Catalyst for the β-Selective C-H Bond Arylation of Thiophenes with Iodoarenes
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DOI：
10.1002/anie.201005082
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发表时间：
2010-01-01
影响因子：
16.6
通讯作者：
Itami, Kenichiro
中科院分区：
文献类型：
--
作者：
Ueda, Kirika;Yanagisawa, Shuichi;Itami, Kenichiro
开放获取：噻吩通常反应性较低的β位以前无法直接功能化。然而，在PdCl 2/P {OCH (CF 3) 2} 3/Ag 2 CO 3催化体系下，噻吩与碘芳烃（见图）的芳基化反应中，β选择性是一种非常普遍的现象，适用于未取代、单取代和二取代的噻吩衍生物，以及含噻吩的融合芳香化合物。
Open access: The normally less-reactive β position of thiophenes was previously inaccessible to direct functionalization. However, the β selectivity observed with the catalytic system PdCl 2/P {OCH (CF 3) 2} 3/Ag 2 CO 3 in the arylation of thiophenes with iodoarenes (see scheme) is a remarkably general phenomenon applicable to unsubstituted, monosubstituted, and disubstituted thiophene derivatives, as well as thiophene-containing fused aromatic compounds.