Ice-microsphere templating to produce highly porous nanocomposite PLA matrix scaffolds with pores selectively lined by bacterial cellulose nano-whiskers
Ice-microsphere templating to produce highly porous nanocomposite PLA matrix scaffolds with pores selectively lined by bacterial cellulose nano-whiskers
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DOI：
10.1016/j.compscitech.2010.05.028
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发表时间：
2010-11-15
影响因子：
9.1
通讯作者：
Bismarck, A.
中科院分区：
文献类型：
--
作者：
Blaker, J. J.;Lee, K. -Y.;Bismarck, A.
通过提供受控纳米谱的组织工程的3D支架的生产仍然是一个重大挑战，在这里，我们将冰微环模板技术与热诱导的相位分离结合在一起，并利用亲水性和疏水相之间的相互作用。用细菌纤维素纳米鞭子在孔壁上衬里，我们开发的低温技术不仅允许装饰带有纳米鞭子的3D多孔形式的孔壁，而且还可以控制孔结构，互连和表面积。此外，我们的新型组合溶剂提取和冰升华途径在本文中保留了冷冻结构。 （c）2010 Elsevier Ltd保留所有权利
The production of 3D scaffolds for tissue engineering with provision of a controlled nano-topography remains a significant challenge Here we have combined an ice-microsphere templating technique with thermally induced phase separation, and by taking advantage of interactions between hydrophilic and hydrophobic phases. lined the pore walls with bacterial cellulose nano-whiskers The cryogenic technique we have developed not only allows the decoration of the pore walls of 3D porous forms with nano-whiskers but also enables the pore structure, Interconnects and surface area to be controlled. Moreover our novel combined solvent extraction and ice sublimation route presented herein preserves the frozen-in structure. (C) 2010 Elsevier Ltd All rights reserved