Reciprocal control of T helper cell and dendritic cell differentiation
Reciprocal control of T helper cell and dendritic cell differentiation
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DOI：
10.1126/science.283.5405.1183
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发表时间：
1999-02-19
期刊：
影响因子：
56.9
通讯作者：
Liu, YJ
中科院分区：
文献类型：
--
作者：
Rissoan, MC;Soumelis, V;Liu, YJ
目前尚不清楚树突状细胞的亚群是否提供不同的细胞因子微环境，决定1型T辅助细胞（T（H）1）或T（H）2细胞的分化。发现人单核细胞（pDC 1）衍生的树突状细胞（DC 1）诱导T（H）1分化，而来自CD 4（+）CD 3（-）CD 11 c（-）浆细胞样细胞（pDC 2）的树突状细胞（DC 2）通过使用不受白细胞介素-4（IL-4）或IL-12影响的机制诱导T（H）2分化。T（H）2细胞因子IL-4促进DC 1成熟并杀死pDC 2，IL-10可增强这种作用，但CD 40配体和干扰素-γ可阻断这种作用。因此，来自成熟T辅助细胞的负反馈环可通过调节适当树突状细胞亚群的存活来选择性地抑制延长的T（H）1或T（H）2应答。
It is not known whether subsets of dendritic cells provide different cytokine microenvironments that determine the differentiation of either type-1 T helper (T(H)1) or T(H)2 cells. Human monocyte (pDC1)-derived dendritic cells (DC1) were found to induce T(H)1 differentiation, whereas dendritic cells (DC2) derived from CD4(+)CD3(-)CD11c(-) plasmacytoid cells (pDC2) induced T(H)2 differentiation by use of a mechanism unaffected by interleukin-4 (IL-4) or IL-12. The T(H)2 cytokine IL-4 enhanced DC1 maturation and killed pDC2, an effect potentiated by IL-10 but blocked by CD40 Ligand and interferon-gamma, Thus, a negative feedback Loop from the mature T helper cells may selectively inhibit prolonged T(H)1 or T(H)2 responses by regulating survival of the appropriate dendritic cell subset.