Metabolism of prostaglandins E, A, and C in serum.
Metabolism of prostaglandins E, A, and C in serum.
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血清中前列腺素 E、A 和 C 的代谢。
DOI：
10.1016/s0021-9258(19)41907-8
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
L. Levine
中科院分区：
文献类型：
--
作者：
H. Polet;L. Levine
在人血清中检测到三种前列腺素代谢酶。一种是将前列腺素E转化为前列腺素A的脱水酶，第二种是将前列腺素A转化为前列腺素C的前列腺素A异构酶，第三种是将前列腺素C转化为前列腺素B的前列腺素C异构酶。在人血清中，只有前列腺素C异构酶具有较高的活性，而其他两种酶的活性很低。兔血清中两种异构酶活性均很高，但未检测到脱水酶活性。结晶的人血清白蛋白和兔血清白蛋白中也有前列腺素C异构酶活性。
Three prostaglandin-metabolizing enzymes were detected in human serum. One enzyme was a dehydrase that converted prostaglandin E to prostaglandin A, the second was a prostaglandin A isomerase that converted prostaglandin A to prostaglandin C and the third was a prostaglandin C isomerase that converted prostaglandin C to prostaglandin B. All three were inactivated by sulfhydryl blocking agents. In human serum, only prostaglandin C isomerase had high activity, whereas the two other enzymes had very low activity. In rabbit serum both isomerases were very active, but dehydrase activity could not be detected. Prostaglandin C isomerase activity was also found in crystallized human serum albumin and rabbit serum albumin.