Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study
Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study
复制标题
DOI：
10.1093/aje/kwi085
复制
发表时间：
2005-04-01
影响因子：
5
通讯作者：
Willett, WC
中科院分区：
文献类型：
--
作者：
Oh, K;Hu, FB;Willett, WC
作者研究了 1980 年 78,778 名最初没有心血管疾病和糖尿病的美国女性中膳食脂肪和特定类型的脂肪与冠心病 (CHD) 风险之间的关系。他们在 20 年的随访期间记录了 1,766 例 CHD 病例（包括 1,241 例非致命性心肌梗死和 525 例 CHD 死亡）。多不饱和脂肪摄入量与 CHD 风险呈负相关（最高与最低五分位的多变量相对风险 (RR) = 0.75，95% 置信区间 (CI)：0.60, 0.92；p（趋势）= 0.004），而反式脂肪摄入量与 CHD 风险升高相关（RR = 1.33，95% CI：1.07，1.66；p（趋势）= 0.004）。 p（趋势）= 0.01）。多不饱和脂肪和反式脂肪摄入量与冠心病风险之间的关联在 65 岁以下的女性中最为明显（对于多不饱和脂肪，RR = 0.66，95% CI：0.50，0.85；p（趋势）= 0.002；对于反式脂肪，RR = 1.50，95% CI：1.13，2.00；p（趋势）= 0.01）。在体重指数 >= 25 kg/m(2) 的女性中，多不饱和脂肪摄入量与冠心病风险之间的负相关性最强。研究结果继续支持多不饱和脂肪摄入量与冠心病风险之间存在反比关系，特别是在年轻或超重的女性中。此外，反式脂肪的摄入量与冠心病风险增加有关，特别是对于年轻女性。
The authors examined the associations of dietary fat and specific types of fat with risk of coronary heart disease (CHD) among 78,778 US women initially free of cardiovascular disease and diabetes in 1980. They documented 1,766 incident CHD cases (including 1,241 nonfatal myocardial infarctions and 525 CHD deaths) during 20 years of follow-up. Polyunsaturated fat intake was inversely associated with CHD risk (multivariate relative risk (RR) for the highest vs. the lowest quintile = 0.75, 95% confidence interval (CI): 0.60, 0.92; p(trend) = 0.004), whereas transfat intake was associated with an elevated risk of CHD (RR = 1.33, 95% CI: 1.07, 1.66; p(trend) = 0.01). The associations between intakes of polyunsaturated fat and trans-fat with CHD risk were most evident among women younger than age 65 years (for polyunsaturated fat, RR = 0.66, 95% CI: 0.50, 0.85; p(trend) = 0.002 and for transfat, RR = 1.50, 95% CI: 1.13, 2.00; p(trend) = 0.01). The inverse association between polyunsaturated fat intake and CHD risk was strongest among women whose body mass index was >= 25 kg/m(2). Findings continue to support an inverse relation between polyunsaturated fat intake and CHD risk, particularly among younger or overweight women. In addition, trans-fat intake was associated with increased risk of CHD, particularly for younger women.