Nickel-catalyzed Kumada Cross-coupling Reaction for the Synthesis of 2,4-Diarylquinazolines
Nickel-catalyzed Kumada Cross-coupling Reaction for the Synthesis of 2,4-Diarylquinazolines
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镍催化 Kumada 交叉偶联反应合成 2,4-二芳基喹唑啉
DOI：
10.1002/jhet.2513
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发表时间：
2016
影响因子：
2.4
通讯作者：
Yiyuan Peng
中科院分区：
文献类型：
--
作者：
Xinglin Ye;Zhihan Yuan;Yirong ahou;Qin Yang;Yepeng Xie;Zhihong Deng;Yiyuan Peng
通过镍催化的喹唑啉-4-甲苯磺酸酯与芳基格氏试剂的交叉偶联反应，成功地合成了一系列2，4-二芳基喹唑啉，为喹唑啉的C4位引入芳基提供了一种新的直接途径。
A series of 2,4‐diarylquinazolines have been successfully synthesized via the Ni‐catalyzed cross‐coupling reaction of quinazoline‐4‐tosylates and aryl Grignard reagents, which provided alternative straightforward approaches for the introduction of aryl groups to quinazolines at C‐4 position.