Proteinuria is a prognostic marker for cardiovascular mortality: NIPPON DATA 80, 1980-1999
Proteinuria is a prognostic marker for cardiovascular mortality: NIPPON DATA 80, 1980-1999
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DOI：
10.2188/jea.15.146
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发表时间：
2005-07-01
影响因子：
4.7
通讯作者：
Ueshima, H
中科院分区：
文献类型：
--
作者：
Tanihara, S;Hayakawa, T;Ueshima, H
背景：蛋白尿被认为是糖尿病患者的预后指标，但关于普通人群中蛋白尿与死亡率之间关系的研究数量有限。 方法：研究对象为参加 1980 年全国心血管调查的 10,897 名受试者，年龄为 30 岁以上，居住在日本全国随机选择的 300 个地区。生命记录于 1999 年得到确认，对研究开始时没有高血压、中风、心脏病、肾病或糖尿病史的 7,203 名受试者（3,180 名男性和 4,023 名女性）进行了调查。结果：随访人数为 126,825 人年。在观察期间，有 371 人死于心血管原因，其中 171 人死于中风，74 人死于冠心病。在调整年龄和其他心血管疾病危险因素后，蛋白尿导致心血管死亡的风险大于血清肌酐水平正常的人群。结论：与其他心血管疾病危险因素相比，尿蛋白是日本人群心血管死亡的独立危险因素。
Background: Proteinuria has been considered to be a prognostic marker for persons with diabetes mellitus, but only a limited number of studies about the relationship between proteinuria and mortality among general population has been available.Methods: The subjects were 10,897 individuals who participated in the National Cardiovascular Survey conducted in 1980 and who were aged 30 years or older living in 300 districts that had been randomly selected throughout Japan. The vital records were confirmed in 1999 and 7,203 subjects (3,180 males and 4,023 females) without a history of hypertension, stroke, heart disease, renal disease, or diabetes mellitus at the start of the study were investigated.Results: There were 126,825 person-years of follow-up. During the observed period of time, 371 died of cardiovascular causes, including 171 stroke deaths and 74 coronary deaths. The risk of proteinuria for cardiovascular mortality was greater than unity for those with a normal serum creatinine level, after adjusting for age and other cardiovascular disease risk factors.Conclusions: When contrasted with other cardiovascular disease risk factors, urinary protein is an independent risk factor for cardiovascular death among the Japanese population.