Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma.
Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma.
复制标题
肿瘤细胞中 Foxp3 过度表达预示口腔鳞状细胞癌的生存率较差。
DOI：
10.1186/s12885-016-2419-6
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发表时间：
2016-07-26
期刊：
影响因子：
3.8
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Song JJ;Zhao SJ;Fang J;Ma D;Liu XQ;Chen XB;Wang Y;Cheng B;Wang Z
叉头盒P3（Foxp3）是一种调节性T细胞标志物，其表达与许多恶性肿瘤的预后相关。本研究旨在探讨Foxp3在口腔鳞状细胞癌（OSCC）中的表达与临床病理参数及预后的关系。采用免疫组织化学方法检测273例口腔鳞癌石蜡包埋组织中Foxp3的表达。统计分析Foxp3表达与口腔鳞癌临床病理特征及预后的关系。Foxp3蛋白表达与淋巴结转移显著相关（P <0.01）。单因素和多因素分析均显示Foxp3是影响5年总生存率（OS）和无复发生存率（RFS）的独立因素（均P <0.01）。Foxp3过表达的患者OS和RFS较短。我们的研究结果表明，Foxp3蛋白表达升高是OSCC预后的预测因素，并可能成为一个有前途的治疗靶点。
Forkhead Box P3 (Foxp3) is a regulatory T cells marker, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of Foxp3 expression with clinicopathological parameters and prognosis in oral squamous cell carcinoma (OSCC). Foxp3 expression was examined using immunohistochemistry (IHC) in paraffin-embedded tissue samples from 273 OSCC patients. Statistical analysis was performed to evaluate the associations between Foxp3 expression, the clinicopathologic characteristics and prognostic factors in OSCC. Foxp3 protein expression was significantly associated with lymph node metastasis (P <0.01). Both univariate and multivariate analyses revealed that Foxp3 was an independent factor for both 5 years overall survival (OS) and relapse-free survival (RFS) (both P <0.01). Patients with Foxp3 overexpression had shorter OS and RFS. Our results determined that elevated Foxp3 protein expression was a predictive factor of outcome in OSCC and could act as a promising therapeutic target.