Phase-Transfer-Catalyzed EnantioselectiveAlkylation of α-Benzoyloxy-β-Keto Ester
Phase-Transfer-Catalyzed EnantioselectiveAlkylation of α-Benzoyloxy-β-Keto Ester
复制标题
相转移催化 α-苯甲酰氧基-β-酮酯的对映选择性烷基化
作者：
T. Hashimoto;K. Sasaki;K. Fukumoto;Yuichi Murase;T. Ooi;K. Maruoka
以N-螺环手性季铵盐为相转移催化剂，可以实现2-苯甲酰氧基-3-氧代丁酸叔丁酯的高对映选择性烷基化反应，作为α-烷基-β-酮酯不对称羟基化反应的补充。
Highly enantioselective alkylation of tert-butyl 2-benzoyloxy-3-oxobutanoate could be realized by the use of N-spiro chiral quaternary ammonium salt as phase-transfer catalyst, as a complementary approach to the asymmetric hydroxylation of α-alkyl-β-keto esters.