Studies towards the total synthesis of palau'amine. Formation of 4,5-dihydropyrrole-2-carboxylate intermediates by alkene-enamide ring-closing metathesis
Studies towards the total synthesis of palau'amine. Formation of 4,5-dihydropyrrole-2-carboxylate intermediates by alkene-enamide ring-closing metathesis
复制标题
DOI：
10.1016/j.tet.2004.06.140
复制
发表时间：
2004-10-18
期刊：
影响因子：
2.1
通讯作者：
Overman, LE
中科院分区：
文献类型：
--
作者：
Katz, JD;Overman, LE
通过烯烃-烯酰胺闭环复分解反应组装了高度官能化的4，5-二氢吡咯-2-羧酸酯。随后的分子内偶氮甲亚胺偶极环加成提供了在帕劳'胺的全合成中潜在使用的三氮杂环戊二烯并[cd]并环戊二烯中间体。(C)2004爱思唯尔有限公司保留所有权利。
A highly functionalized 4,5-dihydropyrrole-2-carboxylate is assembled by alkene-enamide ring-closing metathesis. Subsequent intramolecular azomethine imine dipolar cycloaddition provides a triazacyclopenta[cd]pentalene intermediate of potential use in a total synthesis of palau'amine. (C) 2004 Elsevier Ltd. All rights reserved.