Rat intralaminar thalamic nuclei projections to the globus pallidus: a biotinylated dextran amine anterograde tracing study.
Rat intralaminar thalamic nuclei projections to the globus pallidus: a biotinylated dextran amine anterograde tracing study.
复制标题
大鼠层内丘脑核投射至苍白球：生物素化右旋糖酐胺顺行追踪研究。
DOI：
10.1002/cne.20029
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Kita,H
中科院分区：
文献类型：
--
作者：
Yasukawa,T;Kita,T;Xue,Y;Kita,H
用生物素葡聚糖胺（BDA）顺行追踪法研究了大鼠丘脑板内核（ITN）向苍白球（GP）投射的形态结构和超微结构特征。为了评估ITN中BDA注射部位的功能相关性，使用了ITN-新纹状体（Str）投射的已知拓扑结构以及Str和GP的钙结合蛋白（CaBP）免疫染色模式。在外侧束旁核的外侧部和中央外侧核的尾部注射BDA，标记的纤维和终扣主要位于Str的背外侧感觉运动区和GP的中部区域。在束旁外侧核内侧部和中央外侧核注射BDA，主要标记Str的中联合区和GP的边缘区和尾内侧区。在内侧束旁核和中央内侧核注射BDA主要标记了Str.内侧束旁核投射到GP的最内侧区域，而中央内侧核向GP的投射非常稀疏。电镜观察表明，BDA标记的终扣主要在GP中直径为0.5 - 2.0 μ m的树突轴上形成不对称突触。终扣较小，但有一个相对较长的活动区。目前的观察结果与已知的纹状体-苍白球投射的地形学组织一起表明，ITN-GP投射在地形学上与ITN-Str投射平行。因此，ITN投射到Str的感觉运动区、联合区和边缘区的每一部分也投射到GP的相应功能区。J.Comp.神经元471：153 - 167，2004.© 2004 Wiley利斯公司
The topographical organization and ultrastructural features of the intralaminar thalamic nuclei (ITN) projections to the globus pallidus (GP) were studied using the biotinylated dextran amine (BDA) anterograde tracing method in the rat. To assess the functional association of BDA injection sites in the ITN, the known topographical organization of the ITN‐neostriatal (Str) projections and calcium binding protein (CaBP) immunostaining patterns of the Str and GP were used. BDA injection in the lateral part of the lateral parafascicular nucleus and the caudal part of the central lateral nucleus labeled fibers and boutons mainly in the dorsolateral sensorimotor territory of the Str and the middle territories of the GP. BDA injection in the medial part of the lateral parafascicular nucleus and the central lateral nucleus labeled mainly the middle association territory of the Str and the border and the caudomedial territories of the GP. BDA injection in the medial parafascicular nucleus and the central medial nucleus labeled mainly the medial limbic territory of the Str. The medial parafascicular nucleus projected to the medial‐most region of the GP, while the central medial nucleus projection to the GP was very sparse. Electron microscopic observations indicated that BDA‐labeled boutons form asymmetric synapses mainly on 0.5–2.0 μm diameter dendritic shafts in the GP. The boutons were small but had a relatively long active zone. The present observations together with the known topographical organization of striatopallidal projections indicated that the ITN‐GP projections were topographically organized in parallel to the ITN‐Str projections. Thus, each part of the ITN projecting to the sensorimotor, the association, and the limbic territories of the Str also projects to the corresponding functional territories of the GP. J. Comp. Neurol. 471:153–167, 2004. © 2004 Wiley‐Liss, Inc.