Cross-linking mechanisms of calcium and zinc in production of alginate microspheres
Cross-linking mechanisms of calcium and zinc in production of alginate microspheres
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DOI：
10.1016/s0378-5173(02)00169-2
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发表时间：
2002-08-21
影响因子：
5.8
通讯作者：
Heng, PWS
中科院分区：
文献类型：
--
作者：
Chan, LW;Jin, Y;Heng, PWS
以氯化钙和硫酸锌为交联剂，采用乳化法制备海藻酸钠微球。这两种盐的组合交联的微球显示出不同的形态和缓慢的药物释放相比，由钙盐单独交联。从粘度研究中发现，锌阳离子与海藻酸盐分子的相互作用程度大于钙阳离子。盐对微球性质的不同影响主要归因于它们与藻酸盐分子相互作用的能力。(C)2002 Elsevier Science B.V.保留所有权利。
Calcium chloride and zinc sulphate were used to cross-link alginate microspheres prepared by an emulsification method. The microspheres cross-linked by a combination of these two salts showed different morphology and slower drug release compared with those cross-linked by the calcium salt alone. From viscosity study, it was found that zinc cations interacted with the alginate molecules to a greater extent than calcium cations. The varying effects of the salts on the properties of the microspheres were largely attributed to their ability to interact with the alginate molecules. (C) 2002 Elsevier Science B.V. All rights reserved.