Co-regulator Interactions in Krüppel-like Factor Transcriptional Programs
Co-regulator Interactions in Krüppel-like Factor Transcriptional Programs
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DOI：
10.1007/978-4-431-87775-2_4
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
Richard C. M. Pearson;Briony H. A. Jack;S. Lee;Alister P. W. Funnell;M. Crossley
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文献类型：
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作者：
Richard C. M. Pearson;Briony H. A. Jack;S. Lee;Alister P. W. Funnell;M. Crossley
KRüppel-like转录因子(KLF)是一个基因调控蛋白家族，在细胞的增殖、存活和分化中起着不同的作用。KLF含有三个特征的、高度保守的C-末端锌指，它们协调序列特异的DNA结合。尽管具有高度同源的DNA结合域，但家族成员能够调控不同的靶基因的表达，从而导致对分化的时间和组织特异性控制。为了做到这一点，KLFS进化出了不同的N-末端调节域，允许与各种协同调节因子相互作用。本章描述了与KLF相互作用的辅助因子，并概述了这些相互作用如何增强或抑制KLF转录活性，它们如何帮助定义靶基因特异性，以及它们如何决定基因是激活还是抑制。
Krüppel-like transcription factors (KLFs) comprise a family of gene regulatory proteins with diverse roles in cellular proliferation, survival, and differentiation. KLFs contain three characteristic, highly conserved C-terminal zinc fingers that coordinate sequence-specific DNA binding. Despite having highly homologous DNA binding domains, family members are able to regulate the expression of diverse target genes, resulting in both temporal and tissue-specific control of differentiation. To do this, KLFs have evolved distinct N-terminal regulatory domains that allow interaction with various co-regulators. This chapter describes the cofactors that interact with KLFs and outlines how these interactions potentiate or inhibit KLF transcriptional activity, how they help define target gene specificity, and how they dictate whether a gene is activated or repressed.