Brain and Kidney d‐Amino Acid Oxidases Are Coded by a Single Gene in the Mouse
Brain and Kidney d‐Amino Acid Oxidases Are Coded by a Single Gene in the Mouse
复制标题
小鼠大脑和肾脏 d-氨基酸氧化酶由单个基因编码
DOI：
10.1111/j.1471-4159.1984.tb02718.x
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发表时间：
1984
影响因子：
4.7
通讯作者：
Y. Yasumura
中科院分区：
文献类型：
--
作者：
R. Konno;Y. Yasumura
翻译后摘要：突变小鼠（ddYIDAO−）缺乏d-氨基酸氧化酶在肾脏中也缺乏这种酶在大脑中。遗传交叉实验表明，大脑中的酶的遗传与肾脏中的相同。大脑中酶的缺乏不能与肾脏中的酶分开。脑和肾酶显示出相似的底物特异性。这些结果表明，小鼠脑和肾D-氨基酸氧化酶由相同的基因编码。
Abstract: Mutant mice (ddYIDAO−) lacking d‐amino acid oxidase in the kidney also lacked this enzyme in the brain. Genetic cross experiments showed that the inheritance of the enzyme in the brain was the same as that in the kidney. The deficiency in the enzyme in the brain could not be separated from that in the kidney. The brain and kidney enzymes showed similar substrate specificities. These results suggest that brain and kidney d‐amino acid oxidases are coded by the same gene in the mouse.