Smoking, oral contraceptives, and serum lipid and lipoprotein levels in youths.
Smoking, oral contraceptives, and serum lipid and lipoprotein levels in youths.
复制标题
青少年吸烟、口服避孕药以及血清脂质和脂蛋白水平。
DOI：
10.1016/0091-7435(82)90001-9
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发表时间：
1982
影响因子：
5.1
通讯作者：
Berenson,GS
中科院分区：
文献类型：
--
作者：
Voors,AW;Srinivasan,SR;Hunter,SM;Webber,LS;Sklov,MC;Berenson,GS
为了研究吸烟对青少年心血管危险因素的影响，我们调查了3,145名8-17岁的儿童。（88%符合条件的地理人口; 65%白色和35%黑人）的血脂和脂蛋白，人体测量，和其他危险因素，管理吸烟问卷（包括年龄较大的女孩口服避孕药的问题），并验证吸烟史与血浆硫氰酸盐水平。在78%资料完整的被检儿童中，吸烟与空腹血清α-脂蛋白（控制年龄）的偏相关系数仅在白色女孩中呈显著负相关（P< 0.01）。14名白色女孩和17名黑人女孩报告使用口服避孕药，这与β-脂蛋白胆固醇超过34和13 mg/dl有关（P<0.0001，P < 0.05）和40和23 mg/dl甘油三酯（P<0.0001，P < 0.0005），白人和黑人α-脂蛋白胆固醇分别降低19和3 mg/dl（P<0.0001，P < 0.01）。血清脂质或脂蛋白对这些刺激的反应可能受到种族的影响。
To examine the effect of smoking on cardiovascular risk factors in youth, we examined 3,145 children ages 8–17 years (88% of the eligible geographic population; 65% white and 35% black) for serum lipids and lipoproteins, anthropometry, and other risk factors, administered a smoking questionnaire (including questions on oral contraceptives for older girls), and validated the smoking history with plasma thiocyanate levels. For the 78% of examined children with complete data, the coefficient of partial correlation between smoking and fasting serum α-lipoprotein (controlling for age) was significantly negative only in white girls (P< 0.01). Fourteen white girls and seventeen black girls reported use of oral contraceptives which was associated with an excess of 34 and 13 mg/dl β-lipoprotein cholesterol (P< 0.0001,P< 0.05) and of 40 and 23 mg/dl triglycerides (P< 0.0001,P< 0.0005), and with a deficit of 19 and 3 mg/dl α-lipoprotein cholesterol (P< 0.0001,P< 0.01) for whites and blacks, respectively. Serum lipid or lipoprotein response to these stimuli may be influenced by race.