LFG: a candidate apoptosis regulatory gene family
LFG: a candidate apoptosis regulatory gene family
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DOI：
10.1007/s10495-009-0402-2
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发表时间：
2009-11-01
期刊：
影响因子：
7.2
通讯作者：
Goldberger, Gabriel
中科院分区：
文献类型：
--
作者：
Hu, Lan;Smith, Temple F.;Goldberger, Gabriel
人类、模型和其他生物体的基因组数据的不断丰富已经允许鉴定凋亡相关基因的独特基因家族。这些基因中的大多数目前未被注释，或者在过去被归入两个可疑的相关基因家族。例如，已报道跨膜Bax抑制剂1（BI 1）基序家族在细胞凋亡中起作用，并且由至少七种哺乳动物蛋白质基因GRINA、BI 1、Lfg/FAIM 2、Ghitm、RESC 1/Tmbim 1、GAAP/Tmbim 4和Tmbm 1b组成。然而，一个详细的序列和系统发育分析表明，只有五个这些形成一个明确的和独特的蛋白质家族。现在，这为理解和研究这些蛋白质在模型生物中广泛组织中的生物学作用提供了信息。这些基因之间的进化关系提供了一个强大的前景外推到人类的条件。
The expanding wealth of human, model and other organism's genomic data has allowed the identification of a distinct gene family of apoptotic related genes. Most of these genes are currently unannotated or have been subsumed under two questionably related gene families in the past. For example the transmembrane Bax inhibitor 1 (BI1) motif family has been reported to play a role in apoptosis and to consist of at least seven mammalian protein genes, GRINA, BI1, Lfg/FAIM2, Ghitm, RESC1/Tmbim1, GAAP/Tmbim4, and Tmbm1b. However, a detailed sequence and phylogenetic analysis shows that only five of these form a clear and unique protein family. This now provides information for understanding and investigating the biological roles of these proteins across a wide range of tissues in model organisms. The evolutionary relationships among these genes provide a powerful prospective for extrapolating to human conditions.