ANTIMUTAGENIC ACTIVITY OF EXTRACTS FROM ANTICANCER DRUGS IN CHINESE-MEDICINE
ANTIMUTAGENIC ACTIVITY OF EXTRACTS FROM ANTICANCER DRUGS IN CHINESE-MEDICINE
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DOI：
10.1016/0165-1218(88)90093-6
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发表时间：
1988-02-01
期刊：
影响因子：
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通讯作者：
LIN, JY
中科院分区：
文献类型：
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作者：
LEE, H;LIN, JY
采用沙门氏菌/微粒体系统，在苦味酸或苯并[a]芘存在下，研究了36种常用抗癌中药提取物的抗突变活性。每种药材用沸水提取2 h，这是中国人常用的制备口服药物的方法。结果表明，多裂凤尾蕨提取物对苦马酸诱发的突变具有最强的抗突变活性。另外6种中草药的提取物对苦味酸诱发的突变也有一定的抗突变作用，它们是：猕猴桃，熏衣草叶蒿和无柄猪屎豆（Crotalaria sessiliflora L.），夏枯草，巴黎和短梗蛇葡萄（Ampelopsis brevipedunculata T.）本文研究了菝葜的提取物，夏枯草中华猕猴桃（Actinidia chinensis P.）能完全抑制苯并[a]芘的致突变性。对苯并[a]芘具有中等抗突变活性的其它12种中草药提取物为：多叶凤尾蕨，短梗蛇葡萄蛇莓，草棉，紫草，大叶蒿，卷柏，石竹，鹅不食草，莪术，通光藤和刺楸Kalopanax septemlobus L.其中有5种药材，猕猴桃，大叶蒿，夏枯草，巴黎和S.短梗蛇葡萄含有针对苦酮酸和苯并[a]芘诱导的突变的抗突变因子。
The antimutagenic activities of extracts of 36 commonly used anticancer crude drugs from Chinese herbs were studied by using the Salmonella/microsomal system in the presence of picrolonic acid or benzo[a]pyrene to test whether they contain direct or indirect antimutagens. Each crude drug was extracted with boiling water for 2 h, the method which is commonly used by Chinese people to prepare the drug for oral intake. The extracts of Pteris multifida P. showed the highest antimutagenic activity against picrolonic acid-induced mutation. The extracts of 6 other different kinds of Chinese herbs were shown to have a moderate antimutagenic activity against picrolonic acid-induced mutation, and they are: Actinidia chinensis P., Artemisia lavandulaefolia DC. and Crotalaria sessiliflora L., Prunella vulgaris L., Paris polyphylla S. and Ampelopsis brevipedunculata T. The extracts of Smilax china L., Prunella vulgaris L. and Actinidia chinensis P. were demonstrated to inhibit the mutagenicity of benzo[a]pyrene completely. The 12 other kinds of extracts of Chinese herbs which had a moderate antimutagenic activity against benzo[a]pyrene were: Pteris polyphylla S., Ampelopsis brevipedunculata T., Duchesnea indica F., Gossypium herbaceum L., Lithospermum erythrorrhizon SZ., Artemisia lavendulaefolia DC., Selaginella doederleinii H., Dianthus superbus L., Centipeda minima ABA., Curcuma zedoaria R., Marsdenia tenacissima WA. and Kalopanax septemlobus L. Among them, there were 5 kinds of crude drugs, Actinidia chinensis P., Artemisia lavendulaefolia DC., Prunella vulgaris L., Paris polyphylla and S. Ampelopsis brevipedunculata T., containing antimutagenic factors against both picrolonic acid- and benzo[a]pyrene-induced mutation.