Closed-Loop Theta Stimulation in the Orbitofrontal Cortex Prevents Reward-Based Learning
Closed-Loop Theta Stimulation in the Orbitofrontal Cortex Prevents Reward-Based Learning
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DOI：
10.1016/j.neuron.2020.02.003
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发表时间：
2020-05-06
期刊：
影响因子：
16.2
通讯作者：
Wallis, Joni D.
中科院分区：
文献类型：
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作者：
Knudsen, Eric B.;Wallis, Joni D.
额叶皮层的神经元振荡被假设在高层次认知的组织中发挥作用。在眶额皮质（OFC）中，在奖励引导行为期间，theta频率（4-8 Hz）存在明显的振荡，但这种振荡是否具有因果意义尚不清楚。一个方法上的挑战是，很难在不影响其他神经信号的情况下操纵θ波，比如单个神经元的放电率。一个潜在的解决方案是使用闭环控制来实时记录θ，并使用该信号来控制对OFC的电微刺激的应用。通过这种方法，我们发现OFC中的θ波振荡对奖励引导学习至关重要，并且它们是由海马（HPC）中的θ波振荡驱动的。通过空间定位和时间精确刺激破坏OFC计算的能力可能会导致涉及OFC功能障碍的神经精神疾病的新治疗策略。
Neuronal oscillations in the frontal cortex have been hypothesized to play a role in the organization of high-level cognition. Within the orbitofrontal cortex (OFC), there is a prominent oscillation in the theta frequency (4-8 Hz) during reward-guided behavior, but it is unclear whether this oscillation has causal significance. One methodological challenge is that it is difficult to manipulate theta without affecting other neural signals, such as single-neuron firing rates. A potential solution is to use closed-loop control to record theta in real time and use this signal to control the application of electrical microstimulation to the OFC. Using this method, we show that theta oscillations in the OFC are critically important for reward-guided learning and that they are driven by theta oscillations in the hippocampus (HPC). The ability to disrupt OFC computations via spatially localized and temporally precise stimulation could lead to novel treatment strategies for neuropsychiatric disorders involving OFC dysfunction.