Lung cancer in individuals less than 50 years of age
Lung cancer in individuals less than 50 years of age
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DOI：
10.1007/s00408-007-9021-2
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发表时间：
2007-09-01
期刊：
影响因子：
5
通讯作者：
Alatas, Fusun
中科院分区：
文献类型：
--
作者：
Ak, Guntulu;Metintas, Muzaffer;Alatas, Fusun
本研究的目的是比较年轻和老年肺癌患者的流行病学、临床和实验室特征以及生存率。我们研究了1990年至2005年1340例经组织病理学诊断为肺癌的患者。根据以前的报告，我们将“年轻”定义为50岁以下的人。患者分为两组：< 50岁（年轻组）和>= 50岁（老年组）。在1340例患者中，179例（13.4%）为年轻组，1161例为老年组。在年轻组中，暴露于职业危险因素是肺癌的危险因素，而在老年组中，吸烟是一个危险因素。在诊断时，胸痛在年轻组中更常见，而在老年组中，咳嗽、呼吸困难和胸部X线片上的肺门扩大更常见。腺癌和小细胞癌的发病率在年轻组中更高，而鳞状细胞癌在老年组中更常见。两个年龄组之间的转移率有显著差异：52.0%的年轻组出现IV期疾病，而老年组为43.5%。尽管不能接受或拒绝抗癌治疗的年轻患者少于老年患者，但两组的总生存率相似。这些数据表明，肺癌在年轻患者中具有不同的病因学特征，这可能具有临床意义。通过根据这些特征规划预防措施，可以实现更有效地利用资源。
The aim of this study was to compare the epidemiologic, clinical, and laboratory characteristics and survival rates of younger and older patients with lung cancer. We studied 1340 patients who were histopathologically diagnosed as having lung cancer from 1990 to 2005. Based on prior reports, we defined "younger" as individuals less than 50 years old. The patients were classified into two groups: < 50 years (the younger group) and >= 50 years (the older group). Of the 1340 patients, 179 (13.4%) were in the younger group and 1161 were in the older group. In the younger group, exposure to occupational risk factors was a risk factor for lung cancer, while in the older group, smoking was a risk factor. At the time of diagnosis, chest pain was more common in the younger group, while in the older group, cough, dyspnea, and hilar enlargement on chest X-ray were more frequent. The incidence of adenocarcinoma and small-cell carcinoma was greater in the younger group, while squamous cell carcinoma was more common in the older group. Metastasis rates were significantly different between the two age groups: 52.0% of the younger group presented with stage IV disease compared with 43.5% of the older group. Although fewer younger than older patients were not able to receive or rejected anticancer therapy, the overall survival was similar in both groups. These data indicate that lung cancer had different etiopathogenetic characteristics in younger patients, which may have clinical implications. By planning preventive measures based on these characteristics, more efficient use of resources can be achieved.