Cocaine sensitization and craving: Differing roles for dopamine and glutamate in the nucleus accumbens
Cocaine sensitization and craving: Differing roles for dopamine and glutamate in the nucleus accumbens
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DOI：
10.1300/j069v20n03_05
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发表时间：
2001-01-01
影响因子：
2.3
通讯作者：
Kalivas, PW
中科院分区：
文献类型：
--
作者：
Cornish, JL;Kalivas, PW
反复服用可卡因会产生持久的神经适应，这种神经适应与对可卡因服用的行为反应增强有关，并导致可卡因成瘾和偏执型精神病的表现。本文综述了长期使用可卡因对伏隔核多巴胺和谷氨酸传递的影响，并讨论了这些变化在药物渴求和复发的起始过程中与药物滥用的关系。最近的研究结果表明，伏核中的谷氨酸传递是复吸寻找药物活动的主要沉淀物，而多巴胺和谷氨酸传递对维持吸毒行为都是重要的。(C)2001，由Haworth Press，Inc.保留所有权利。
The repeated administration of cocaine produces enduring neuroadaptations that are associated with enhanced behavioral responsiveness to cocaine administration and lead to cocaine addiction and the manifestation of paranoid psychosis. This review describes the effect of chronic cocaine administration on dopamine and glutamate transmission in the nucleus accumbens, and discusses the relevance of these changes in the initiation of drug craving and relapse to drug abuse. Recent findings suggest that glutamate transmission in the nucleus accumbens is a dominant precipitator of relapse to drug-seeking activity, whereas both dopamine and glutamate transmission are important for sustaining drug-taking behavior. (C) 2001 by The Haworth Press, Inc. All rights reserved.