Swallow Safety in Infant Pigs With and Without Recurrent Laryngeal Nerve Lesion.
Swallow Safety in Infant Pigs With and Without Recurrent Laryngeal Nerve Lesion.
复制标题
有或没有喉返神经损伤的幼猪的吞咽安全性。
DOI：
10.1007/s00455-020-10099-x
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发表时间：
2020
期刊：
影响因子：
2.6
通讯作者：
Mayerl,ChristopherJ
中科院分区：
文献类型：
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作者：
Stricklen,BethanyM;Bond,LauraE;Gould,FrancoisDH;German,RebeccaZ;Mayerl,ChristopherJ
呼吸消化协调对于哺乳动物的安全喂养至关重要，如果不这样做，可能会导致误吸。使用幼猪模型，我们分析了喉返神经（RLN）损伤对断奶前两个时间点的呼吸消化协调和吞咽安全性的影响。本研究应用高速摄影技术，对23头仔猪在7日龄、17日龄喂饲钡乳后的影像进行纵向记录。我们用体积描记器测量呼吸，并使用婴儿哺乳动物渗透-吸气量表（IMPAS）来识别不安全的吞咽。我们测试了对照组和病变组猪纵向吞咽安全性的变化，以及四个不同组之间是否存在任何相互作用。在出生后第7天，病变猪表现出的IMPAS评分的频率分布相对于对照猪在第7天，17日龄病变和对照猪的差异。随着时间的推移，喉返神经病变后的表现存在纵向变化，这表明喉返神经病变的影响随时间而降低，因为老年病变猪的表现与老年对照猪相似。我们发现呼吸消化协调对吞咽安全性的影响差异很小，吸气开始延迟较短，反映了年轻病变猪的渗透率较高。健康猪的吸气速率与喉返神经病变猪相似，表明婴儿偶尔发生吞咽困难可能是正常行为。
Aerodigestive coordination is critical for safe feeding in mammals, and failure to do so can result in aspiration. Using an infant pig model, we analyzed the impact of recurrent laryngeal nerve (RLN) lesion on aerodigestive coordination and swallow safety at two time points prior to weaning. We used high-speed videofluoroscopy to record 23 infant pigs longitudinally at two ages (7 days, 17 days) feeding on barium milk. We measured respiration with a plethysmograph and used the Infant Mammalian Penetration–Aspiration Scale (IMPAS) to identify unsafe swallows. We tested for changes in swallow safety longitudinally in control and lesion pigs, and whether there was any interaction between the four different groups. On postnatal day 7, lesioned pigs exhibited differences in the frequency distribution of IMPAS scores relative to control pigs on day 7, and 17 day old lesion and control pigs. There were longitudinal changes in performance following RLN lesion through time, suggesting that the impact of RLN lesion decreases with time, as older lesioned pigs performed similarly to older control pigs. We found minimal differences in the impact of aerodigestive coordination on swallow safety, with shorter delays of inspiration onset reflecting higher rates of penetration in young lesioned pigs. Healthy pigs aspirated at a similar rate to those with an RLN lesion indicating that the occasional occurrence of dysphagia in infants may be a normal behavior.