Locations of bone tissue at high risk of initial failure during compressive loading of the human vertebral body
Locations of bone tissue at high risk of initial failure during compressive loading of the human vertebral body
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DOI：
10.1016/j.bone.2007.05.017
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发表时间：
2007-10-01
期刊：
影响因子：
4.1
通讯作者：
Keaveny, Tony M.
中科院分区：
文献类型：
--
作者：
Eswaran, Senthil K.;Gupta, Atul;Keaveny, Tony M.
了解椎体内初始失能区域的位置——皮质壳、皮质终板与骨小梁，以及解剖位置——可能有助于提高对衰老、疾病和治疗机制的理解。本研究的总体目的是确定在承受压缩载荷时椎体内骨组织初始衰竭风险最高的位置。为此，基于微ct的60微米体素级线性弹性有限元模型通过模拟椎间盘对13名老年女性（年龄范围：5487岁，75 +/- 9岁）全椎体进行了虚拟加载压缩。所有在每个椎体内的最大或最小主应变超过其第90个百分位数的骨组织被定义为该特定椎体内初始衰竭风险最高的组织。我们的研究结果显示，这种高危组织首先发生在小梁骨，并且在小梁骨中也发生了最大比例的高危组织。皮质终板内及其附近的高危组织数量明显大于中横区。无论假设模拟椎间盘的泊松比如何，皮质终板中高危组织的数量与皮质壳中的相当或更大。我们的研究结果为人类椎体内骨小梁和皮质骨衰竭的微观力学提供了新的见解，并且综合起来表明，在椎体剧烈压缩载荷期间，终板附近和包括终板在内的组织处于初始衰竭的最高风险。(C) 2007爱思唯尔公司版权所有。
\Knowledge of the location of initial regions of failure within the vertebra - cortical shell, cortical endplates vs. trabecular bone, as well as anatomic location - may lead to improved understanding of the mechanisms of aging, disease and treatment. The overall objective of this study was to identify the location of the bone tissue at highest risk of initial failure within the vertebral body when subjected to compressive loading. Toward this end, micro-CT-based 60-micron voxel-sized, linearly elastic, finite element models of a cohort of thirteen elderly (age range: 5487 years, 75 +/- 9 years) female whole vertebrae without posterior elements were virtually loaded in compression through a simulated disc. All bone tissues within each vertebra having either the maximum or minimum principal strain beyond its 90th percentile were defined as the tissue at highest risk of initial failure within that particular vertebral body. Our results showed that such high-risk tissue first occurred in the trabecular bone and that the largest proportion of the high-risk tissue also occurred in the trabecular bone. The amount of high-risk tissue was significantly greater in and adjacent to the cortical endplates than in the mid-transverse region. The amount of high-risk tissue in the cortical endplates was comparable to or greater than that in the cortical shell regardless of the assumed Poisson's ratio of the simulated disc. Our results provide new insight into the micromechanics of failure of trabecular and cortical bone within the human vertebra, and taken together, suggest that, during strenuous compressive loading of the vertebra, the tissue near and including the endplates is at the highest risk of initial failure. (C) 2007 Elsevier Inc. All rights reserved.