Virus-Induced Models for Type 1 Diabetes in Mice
Virus-Induced Models for Type 1 Diabetes in Mice
复制标题
病毒诱导的 1 型糖尿病小鼠模型
DOI：
10.1007/978-1-4614-4051-2_25
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
von Herrath M.G.
中科院分区：
文献类型：
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作者：
Christen U.;von Herrath M.G.
流行病学和实验数据强烈表明，1 型糖尿病的发生是遗传倾向和环境触发因素的有害组合。由于流行病学关联以及从胰腺 1 型糖尿病患者中直接分离，病毒被认为是 1 型糖尿病的病因学中的环境触发因素。病毒诱导的 1 型糖尿病的概念已被用作多种小鼠模型的实验基础。综述了病毒诱导的动物模型如何帮助了解自身免疫介导的糖尿病的发病机制。我们打算回顾从动物模型中获得的这些发现如何帮助设计针对 1 型糖尿病的新型治疗干预措施。
Epidemiological and experimental data strongly suggest that type 1 diabetes occurs as a detrimental combination of genetic predisposition and environmental triggering factors. Viruses have been implicated in the etiology of type 1 diabetes as environmental triggers due to epidemiological association as well as by direct isolation from pancreatic type 1 diabetes patients. The concept of virus-induced type 1 diabetes has been used as an experimental basis in several mouse models. Studies are reviewed on how virus-induced animal models have helped to understand the mechanisms of the pathogenesis of autoimmune-mediated diabetes. We intend to review how such findings obtained from animal models have helped to design novel therapeutic interventions for type 1 diabetes.