Comparative Genomics of Amphibian-like Ranaviruses, Nucleocytoplasmic Large DNA Viruses of Poikilotherms.
Comparative Genomics of Amphibian-like Ranaviruses, Nucleocytoplasmic Large DNA Viruses of Poikilotherms.
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DOI：
10.4137/ebo.s33490
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发表时间：
2015
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影响因子：
--
通讯作者：
Price SJ
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文献类型：
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作者：
Price SJ
最近对大型DNA病毒基因组进化的研究强调了许多可以促进快速适应的令人难以置信的动态过程。两栖类蛙病毒的基因组-双链DNA病毒感染两栖动物，爬行动物和鱼类（虹彩病毒科）-进行了检查，以评估基因组内容和进化过程的变化。所研究的病毒密切相关，但它们的基因组内容差异很大，有29个基因被鉴定出来，并不存在于所有的主要分支中。21个基因有重组的证据，而从圈养爬行动物中分离出的病毒似乎是两个不同亲本的嵌合体。正选择也被发现对超过四分之一的Ranavirus基因起作用，并且在西班牙常见的助产士蟾蜍病毒中最常见，该病毒对两栖动物宿主社区产生了严重影响。通过包含一个外群来解决这一群体的根源的努力是不确定的，但确定了一组核心基因，这恢复了一个得到充分支持的物种树。
Recent research on genome evolution of large DNA viruses has highlighted a number of incredibly dynamic processes that can facilitate rapid adaptation. The genomes of amphibian-like ranaviruses – double-stranded DNA viruses infecting amphibians, reptiles, and fish (family Iridoviridae) – were examined to assess variation in genome content and evolutionary processes. The viruses studied were closely related, but their genome content varied considerably, with 29 genes identified that were not present in all of the major clades. Twenty-one genes had evidence of recombination, while a virus isolated from a captive reptile appeared to be a mosaic of two divergent parents. Positive selection was also found to be acting on more than a quarter of Ranavirus genes and was found most frequently in the Spanish common midwife toad virus, which has had a severe impact on amphibian host communities. Efforts to resolve the root of this group by inclusion of an outgroup were inconclusive, but a set of core genes were identified, which recovered a well-supported species tree.