Neural functional connectivity in patients with periventricular nodular heterotopia-mediated epilepsy
Neural functional connectivity in patients with periventricular nodular heterotopia-mediated epilepsy
复制标题
脑室周围结节性异位介导的癫痫患者的神经功能连接
DOI：
10.1016/j.eplepsyres.2021.106548
复制
发表时间：
2021-01-14
影响因子：
2.2
通讯作者：
Wu, Xintong
中科院分区：
文献类型：
--
作者：
Liu, Wenyu;Yue, Qiang;Wu, Xintong
脑室周围结节性异位（PNH）的特点是神经迁移障碍，通常与癫痫相关。尽管人们认识到 PNH 相关的癫痫，但对大脑水平的潜在功能神经基础知之甚少。因此，我们使用功能磁共振成像 (MRI) 检查 42 名 PNH 相关癫痫受试者和 42 名性别和年龄匹配的健康对照者的神经生物学。对静息状态下的数据进行功能连接（FC）测量和全脑图论分析，以评估神经组织和拓扑结构。 PNH 患者顶叶、扣带回和丘脑的 FC 显着升高，而额顶叶、海马和中央前区的 FC 显着降低。图论分析发现患者和对照组之间没有显着差异，而患者的边缘、小脑网络和枕叶皮层的网络整体效率较低。基于种子的 FC 分析证实了患者远程癫痫网络中的活动和区域间连接的中断，这可能指出了潜在的病理机制。患者的小脑和边缘系统显示出拓扑结构的改变，表明这些区域或中枢可能有助于 PNH 和癫痫的全脑回路。
Periventricular nodular heterotopia (PNH) is characterized by disabled neural migration and is usually associated with epilepsy. Despite awareness of PNH-related epilepsy, little is known about the brain-level underlying functional neural bases. Thus, we used functional magnetic resonance imaging (MRI) to examine the neurobiology of 42 subjects with PNH-related epilepsy and 42 sex- and age-matched healthy controls. Measurements of functional connectivity (FC) and whole-brain graph theory analysis of data in the resting state were performed to assess neurological organization and topology. PNH patients exhibited significantly higher FC in the parietal lobe, cingulum and thalamus, as well as significantly lower FC in frontoparietal, hippocampal, and precentral regions. Graph theory analysis identified no significant differences between patients and controls, while patients showed lower network global efficiency in the limbic and cerebellum network and occipital cortex. Seed-based FC analysis confirmed disruption of activities and interregional connectivity in remote epileptic networks of patients, which may point to underlying pathological mechanisms. The cerebellum and limbic system of patients showed altered topology, suggesting that these regions or hubs may contribute to whole-brain circuits in PNH and epilepsy.