EXTINCTION OF COCAINE-INDUCED PLACE APPROACH IN RATS - A VALIDATION OF THE BIASED CONDITIONING PROCEDURE
EXTINCTION OF COCAINE-INDUCED PLACE APPROACH IN RATS - A VALIDATION OF THE BIASED CONDITIONING PROCEDURE
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DOI：
10.1016/0361-9230(93)90102-h
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发表时间：
1993-01-01
影响因子：
3.8
通讯作者：
SCHECHTER, MD
中科院分区：
文献类型：
--
作者：
CALCAGNETTI, DJ;SCHECHTER, MD
经常被证明的是，当一只老鼠在一个与可卡因注射重复配对的特定线索环境中条件反射时，它在那个环境中的时间比在盐水配对环境中的时间要长。这种行为过程通常被称为条件性位置偏好（CPP）测试。目前，一个坚定的理论理解的机制，生产的CPP是未知的。仅仅知道重复药物配对后会产生CPP是不够的。相反，有必要在学习理论框架内验证该程序。因此，本研究的目的是确定在位置偏好研究中观察到的情况确实如此。条件反射这是通过确定可卡因诱导的在药物配对环境中花费的时间增加是否会在消退试验后减弱来实现的。大鼠在位置调节装置的两个刺激特定室中的一个中花费更多时间的初始偏差进行了测试。在四种情况下，大鼠被注射2.5 mg/kg可卡因，并被限制在它们不太喜欢的房间里，而在四个交替的阶段中，将它们在其优选的室中用盐水（载体）调节。随后在非药物状态下进行的测试显示，与基线测量相比，这些大鼠在最初最不喜欢的环境中花费的时间显着增加。在建立这种可卡因诱导的CPP后，仅用盐水注射大鼠并使其适应相同次数的会话（即，四）。可卡因诱导的增加所花费的时间，随后发现显着衰减相比，nonprevention-treated对照组大鼠。这些结果进行了讨论的条件反射的操作和巴甫洛夫模型。
It has often been demonstrated that when a rat is conditioned in a cue-specific environment that has been repeatedly paired with cocaine injections, it will spend more time in that environment than it does in a saline-paired environment. This behavioral procedure is commonly known as the conditioned place preference (CPP)-test. At present, a firm theoretical understanding of the mechanisms underlying the production of a CPP are unknown. It is insufficient merely to know that a CPP can result after repeated drug pairings. Rather, it is necessary that the procedure is validated within a learning theory framework. The objective of the present study was, therefore, to establish that what is observed in place preference studies was, indeed. conditioning. This was accomplished by determining whether a cocaine-induced increase in time spent in a drug-paired environment was subject to attenuation following extinction trials. Rats were tested for their initial bias in spending more time in one of two stimulus-specific chambers of a place-conditioning apparatus. On four occasions, rats were injected with 2.5 mg/kg cocaine and confined to their less-preferred chamber whereas. on four alternating sessions, they were conditioned with saline (vehicle) in their preferred chamber. Subsequent testing in the nondrugged state revealed that these rats displayed a significant increase in the time spent in their initially least-preferred environment compared to baseline measurements. Following establishment of this cocaine-induced CPP, the rats were injected only with saline and conditioned for an equal number of sessions (i.e., four). The cocaine-induced increase in the time spent was subsequently found to be significantly attenuated in comparison to nonextinction-treated control rats. These results are discussed in terms of operant and Pavlovian models of conditioning.