Cohort Profile: The Kiang West Longitudinal Population Study (KWLPS)-a platform for integrated research and health care provision in rural Gambia
Cohort Profile: The Kiang West Longitudinal Population Study (KWLPS)-a platform for integrated research and health care provision in rural Gambia
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DOI：
10.1093/ije/dyv206
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发表时间：
2017-04-01
影响因子：
7.7
通讯作者：
Fulford, Anthony J.
中科院分区：
文献类型：
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作者：
Hennig, Branwen J.;Unger, Stefan A.;Fulford, Anthony J.
自1950年以来，在冈比亚（西非）的Kiang West地区进行了关于营养不良和疟疾的研究，最初是通过Ian McGregor爵士教授对这个中低收入国家（LMIC）环境中的农村自给农业社区进行的年度人体测量和健康调查（在其他地方有更详细的描述1）。1974年，联合王国医学研究理事会（MRC Keneba）建立了一个永久性的外地站，研究和保健服务扩展到更广泛的社区。MRC Keneba位于下游地区750平方公里的中心地带，该地区直到2014年都只有有限的道路（图1）。最初在KW建立的研究设施是为了支持营养研究，特别是对四个“核心村庄”（居民4000美元）的生长进行纵向研究。自1989年以来，研究还从更广泛的地区招募参与者。综合人口监测[江西人口监测系统（KWDSS）]、电子病历[Keneba电子病历系统（KEMReS）]和生物库平台（Keneba生物库）的建立现在包括一个向整个江西纵向人口研究（KWLPS）队列（36个村庄14 000纳元）提供研究和医疗保健的综合系统。自1949年以来，这项工作主要由英国医学研究理事会（MRC）和英国国际发展部（DFID）根据MRC/DFID协议提供资金支持。
Research on malnutrition and malaria has been conducted in the Kiang West district of The Gambia (West Africa) since 1950, initially through Professor Sir Ian McGregor’s annual anthropometric and health surveys of the rural subsistence farming community in this low-and middle-income country (LMIC) setting (described in more detail elsewhere 1). With the establishment of a permanent field station by the UK Medical Research Council (MRC Keneba) in 1974, research and health provision expanded into the wider community. MRC Keneba is located in the heart of the 750-km 2 district located in the Lower River Region, which until 2014 had limited road access (Figure 1). Research facilities in KW were initially set up to support nutrition studies, in particular for longitudinal studies of growth in four ‘core villages’(with $4000 residents). Since 1989, research studies also recruited participants from the wider district. The establishment of the comprehensive demographic surveillance [Kiang West Demographic Surveillance System (KWDSS)], electronic medical record [Keneba Electronic Medical Records System (KEMReS)] and biobanking platforms (Keneba Biobank) now comprises an integrated system for research and health care provision to the whole of the Kiang West Longitudinal Population Study (KWLPS) cohort (N $14 000 across 36 villages). Since 1949, this work has primarily been supported by funds from the UK Medical Research Council (MRC) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement.